Evaluation of the hydrophobic drug loading characteristics in nanoprecipitated amphiphilic cyclodextrin nanospheres

Pharmaceutical Development and Technology
E Lemos-SennaD Duchêne

Abstract

The aim of this work was to evaluate the loading capacity and the association characteristics of the hydrophobic drug progesterone on amphiphilic cyclodextrin nanospheres prepared by the nanoprecipitation method. The colloidal suspensions were prepared in the presence or absence of two different surfactants, Pluronic F68 and Tween 80. The physicochemical characteristics of the nanospheres were assessed using a nanosizer, zetameter, and transmission electron microscope. The physical state of the drug was verified using differential scanning calorimetry (DSC) and x-ray diffraction (XRD) methods. The in vitro progesterone release was investigated at 37 degrees C after dilution of the suspensions in sink conditions. Nanospheres with a mean diameter from 100 to 300 nm and a low degree of polydispersity were prepared from amphiphilic hexanoyl-gamma-cyclodextrin. The progesterone loading capacity was not affected by the formulation parameters tested. The DSC and XRD studies demonstrated the absence of the crystalline domains of progesterone in loaded nanospheres. The DSC studies also demonstrated the presence of interactions between the drug and carrier. The release of the drug from the carrier was extremely rapid and was governed by ...Continue Reading

References

Oct 1, 1965·Journal of Pharmaceutical Sciences·S G BjaastadA L Thakkar
Jan 1, 1993·Journal of Microencapsulation·M A VandelliR Cameroni

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Citations

Dec 25, 2008·Pharmaceutical Research·Christine Vauthier, Kawthar Bouchemal
Jul 27, 2012·Therapeutic Delivery·Patricia CallejaJuan M Irache
Mar 20, 2001·Journal of Microencapsulation·W J Lin, L I Huang
Aug 27, 2009·Expert Opinion on Drug Delivery·Erem Bilensoy, A Atilla Hincal
Jun 11, 2016·International Journal of Pharmaceutics·Nazlı ErdoğarErem Bilensoy
May 7, 2020·Advanced Pharmaceutical Bulletin·Dipak Dilip Gadade, Sanjay Sudhakar Pekamwar
Nov 20, 2016·International Journal of Pharmaceutics·Dominique Duchêne, Amélie Bochot
Mar 18, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·O Fernando SilvaRita H de Rossi

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