PMID: 11925995Apr 3, 2002Paper

Evaluation of the ICT whole-blood antigen card test to detect infection due to Wuchereria bancrofti in Sri Lanka

Transactions of the Royal Society of Tropical Medicine and Hygiene
T G A N ChandrasenaN R de Silva

Abstract

The sensitivity, specificity and cost effectiveness of an immunochromatographic card test (ICT, AMRAD) for the diagnosis of bancroftian filariasis were estimated against 2 standard parasitological techniques: thick blood film (TBF) and Nuclepore membrane filtration (NMF). Individuals were selected from endemic localities in the Western Province (n = 213) and from the non-endemic Central Province (n = 29) of Sri Lanka. Blood was collected between 21:00 and midnight. Sixty microlitre of non-heparinized blood, and 1 mL and 100 microL of heparinized blood were used in TBF, NMF and ICT, respectively. NMF was positive in 31.5% (67/213) of the endemic group, with a mean microfilaria (mf) count of 343/mL (range 8-1782, SD 422). All 67 were positive by ICT (sensitivity 100%), but only 63 by TBF (sensitivity 94%). Among the endemic population there were 12 who were mf negative but antigen positive by ICT. There were, however, no false positives among the non-endemic controls, indicating the possibility that the ICT may in fact be more sensitive and 100% specific. Thus, ICT filariasis test appears to be more effective (both sensitive and specific) than TBF or NMF in diagnosing infection in lymphatic filariasis. The direct unit recurrent c...Continue Reading

References

Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·D A DenhamF Guy
Sep 1, 1994·The American Journal of Tropical Medicine and Hygiene·P J LammieM L Eberhard
Jun 1, 1994·The American Journal of Tropical Medicine and Hygiene·F AmaralA Coutinho
Sep 1, 1996·The American Journal of Tropical Medicine and Hygiene·G J WeilR Faris
Dec 24, 1997·Lancet·D O FreedmanC Braga
Dec 23, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·M ItohE Kimura
May 1, 1999·Tropical Medicine & International Health : TM & IH·M ItohE Kimura
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·P E Simonsen, S K Dunyo
Feb 28, 2001·The American Journal of Tropical Medicine and Hygiene·A SchuetzP J Lammie
Mar 17, 2001·Tropical Medicine & International Health : TM & IH·D O FreedmanC Braga

❮ Previous
Next ❯

Citations

Apr 15, 2004·Nature Reviews. Microbiology·David MabeyMark D Perkins
Jan 30, 2016·Transactions of the Royal Society of Tropical Medicine and Hygiene·Michael A IrvineT Deirdre Hollingsworth
Jul 31, 2014·Revista Da Sociedade Brasileira De Medicina Tropical·Paula OliveiraAbraham Rocha
Jul 19, 2003·Revista Do Instituto De Medicina Tropical De São Paulo·Cynthia BragaNeal Alexander
Nov 5, 2013·Expert Review of Anti-infective Therapy·Coralie L'Ollivier, Renaud Piarroux
May 27, 2021·Revista Do Instituto De Medicina Tropical De São Paulo·Tália Machado de AssisGláucia Cota

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.