PMID: 6446524Feb 15, 1980Paper

Evaluation of the immunocompetence of macrophages and the generation of T-cell-mediated cytotoxic response against allogeneic tumor cells in tumor bearers

International Journal of Cancer. Journal International Du Cancer
C C Ting, D Rodrigues

Abstract

The present study has examined the competence of peritoneal cells (PC) I of tumor bearers to reverse the immunosuppressive effect of tumor cells, and the ability of the tumor bearers to generate a T-cell-mediated cytotoxic response against allogeneic spleen cells or allogeneic tumor cells. It was found that PC from tumor bearers possess a greater ability to reverse the tumor cell immunosuppression in normal mice. In contrast to normal hosts, the cytotoxic responses of the tumor bearers against allogeneic tumor cells cannot be restored by PC from normal mice or from tumor bearers. The ineffective cytotoxic response in tumor bearers was not due to deficient T responders or T helpers. Rather, it was due to the presence of suppressor cells which were adherent, radioresistant and resistant to anti-Thy-1.2 antibody lysis, and thus were likely to be macrophages. The suppressor macrophages were present only in the spleen and were absent from the peritoneal cavity of the tumor bearers. Their suppressive effect can only be exerted in the presence of tumor cells. These results demonstrate the dichotomy of macrophage function, peritoneal macrophages from the tumor bearers showing increased activity of augmentation of T-cell-response wherea...Continue Reading

References

Jan 1, 1975·Advances in Cancer Research·O Stutman
Jul 15, 1969·International Journal of Cancer. Journal International Du Cancer·S KitD R Dubbs
Nov 1, 1973·Journal of the National Cancer Institute·R B HerbermanR Asofsky
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Aug 1, 1974·Journal of Immunological Methods·I A Ly, R I Mishell
Dec 1, 1950·British Journal of Cancer·P A GORER

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Citations

Aug 27, 2004·Genetic Vaccines and Therapy·Srinivas NagarajIngo GH Schmidt-Wolf
Mar 22, 2015·Cytotherapy·Jeannette CanyNina Shah

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