Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals

Cardiovascular Diabetology
Ki-Bum WonHyuk Jae Chang

Abstract

Data on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited. Data from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry on 12,441 asymptomatic Korean adults (52 ± 9 years, 84.2% males) without previous history of coronary artery disease and stroke, who underwent serial coronary artery calcification (CAC) screening examinations, were included in this study. The median inter-scan period was 3.0 (2.0-4.8) years. All participants were categorized into three groups based on their glycemic status: normal (n = 6578), pre-diabetes (n = 4146), and diabetes (n = 1717). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up CAC scores. The incidence of CAC progression was significantly different between the three groups (normal, 26.3%; pre-diabetes, 30.9%; and diabetes, 46.9%; p < 0.001). In the univariate logistic analysis, the risk of CAC progression was higher in the pre-diabetes (odds ratio [OR] 1.253; 95% confidential interval [CI] 1.150-1.366) and diabetes (OR 2.471; 95% CI 2.215-2.758) groups than in the normal group (p < 0.001, both). In the multivariate l...Continue Reading

References

Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Oct 12, 2000·Journal of the American College of Cardiology·Y AradA D Guerci
Apr 22, 2004·AJR. American Journal of Roentgenology·John E HokansonMarian Rewers
Nov 30, 2005·Journal of Women's Health·Rachel HuxleyUNKNOWN Asia Pacific Cohort Studies Collaboration
May 8, 2007·Journal of the American College of Cardiology·Matthew J BudoffDaniel S Berman
Jan 22, 2008·Journal of the American College of Cardiology·Yamini S LevitzkyCaroline S Fox
Mar 28, 2008·The New England Journal of Medicine·Robert DetranoRichard A Kronmal
Dec 18, 2010·JACC. Cardiovascular Imaging·Matthew J BudoffPaolo Raggi
Mar 26, 2013·Current Diabetes Reports·Janet K Snell-BergeonJohn E Hokanson
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jul 27, 2014·European Heart Journal·Raimund ErbelUNKNOWN Heinz Nixdorf Recall Study Investigators
Jan 7, 2015·JAMA : the Journal of the American Medical Association·UNKNOWN Writing Group for the DCCT/EDIC Research GroupJohn M Lachin
Jun 4, 2015·The New England Journal of Medicine·Rodney A HaywardUNKNOWN VADT Investigators
Feb 11, 2016·Cardiovascular Diabetology·Carlos Henrique Reis Esselin RassiRon Blankstein
May 26, 2017·International Journal of Cardiology·Gyung-Min ParkSang-Gon Lee
Aug 12, 2017·JACC. Cardiovascular Imaging·Søren Zöga DiederichsenAxel Diederichsen
Aug 24, 2017·Cardiovascular Diabetology·Min Kyung KimJong Suk Park

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BETA
imaging techniques

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Statistical Package for the Social Sciences

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