Evaluation of the impact of HMS Plus on postoperative blood loss compared with ACT Plus in cardiac surgery.

Minerva anestesiologica
Arthur BaillyBertrand Rozec

Abstract

The standardized management of anticoagulation during the cardiopulmonary bypass seems inaccurate because of patients and surgeries variability. This study evaluates if an individualized management of heparin and protamine guided by the HMS Plus system during cardiopulmonary bypass could reduce postoperative blood loss. We conducted a prospective, controlled, unblinded, single-center study. One-hundred and eighthy-eight patients operated for cardiac surgery were included. Patients were divided in ACT Plus group (standardized approach) and HMS Plus group (individualized approach). The primary outcome was blood-loss volume during the first 24 postoperative hours. The main secondary outcomes were the need for allogeneic blood transfusions and the final protamine/heparin ratio. There was no difference between the two groups for baseline characteristics. Medium blood-loss volume in the ACT Plus group was 522±260 mL vs. 527±255 mL in the HMS Plus group (P=0.58). The final protamine/heparin ratio in the ACT Plus group was 0.94±0.1 vs. 0.58±0.1 in the HMS Plus group (P<0.0001). The transfusion rate during surgery in the ACT Plus group was 25% vs. 14% in the HMS Plus group (P=0.09). HMS Plus did not reduce the mean blood-loss volume dur...Continue Reading

References

Mar 1, 1984·Clinical Cardiology·C L HollandW Fang
May 1, 1983·American Journal of Hematology·R J Cobel-Geard, H I Hassouna
May 1, 1980·Clinical Pharmacokinetics·J W Estes
May 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·M J MoultonM Rosenbloom
Feb 5, 2000·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·T OhataH Matsuda
Nov 13, 2001·British Journal of Haematology·A J ChuN Ramos
Jul 28, 2004·The Annals of Thoracic Surgery·Shishir KarthikMichael J Desmond
Feb 6, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Robert D SlightPankaj S Mankad
Dec 25, 2009·Circulation. Cardiovascular Quality and Outcomes·Rajendra H MehtaUNKNOWN Society of Thoracic Surgeons National Cardiac Surgery Database Investigators
May 21, 2010·European Journal of Anaesthesiology·Nouman U KhanTimothy Strang
May 31, 2011·The Annals of Thoracic Surgery·Alessandro VivacquaJoseph F Sabik
Feb 2, 2015·Journal of Translational Medicine·Zaishen JiaXiaotong Hou
May 26, 2016·Expert Opinion on Drug Metabolism & Toxicology·Emilia SokolowskaAndrzej Mogielnicki
Oct 13, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Elodie BoissierJean-Christophe Rigal
Oct 14, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Domenico PaganoChrista Boer
Apr 18, 2018·British Journal of Anaesthesia·C BoerA B A Vonk
Dec 26, 2018·Anaesthesia Critical Care & Pain Medicine·Elisabeth ToulouseJean Etienne Bazin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Health Care Quality Assurance
Maria do Carmo Caccia-BavaTor Guimaraes
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Zuo-Jin LiuLv-Nan Yan
© 2021 Meta ULC. All rights reserved