Evaluation of the Implementation of the Response Assessment in Neuro-Oncology Criteria in the HERBY Trial of Pediatric Patients with Newly Diagnosed High-Grade Gliomas

AJNR. American Journal of Neuroradiology
Daniel Rodriguez GutierrezTim Jaspan

Abstract

HERBY was a Phase II multicenter trial setup to establish the efficacy and safety of adding bevacizumab to radiation therapy and temozolomide in pediatric patients with newly diagnosed non-brain stem high-grade gliomas. This study evaluates the implementation of the radiologic aspects of HERBY. We analyzed multimodal imaging compliance rates and scan quality for participating sites, adjudication rates and reading times for the central review process, the influence of different Response Assessment in Neuro-Oncology criteria in the final response, the incidence of pseudoprogression, and the benefit of incorporating multimodal imaging into the decision process. Multimodal imaging compliance rates were the following: diffusion, 82%; perfusion, 60%; and spectroscopy, 48%. Neuroradiologists' responses differed for 50% of scans, requiring adjudication, with a total average reading time per patient of approximately 3 hours. Pseudoprogression occurred in 10/116 (9%) cases, 8 in the radiation therapy/temozolomide arm and 2 in the bevacizumab arm (P < .01). Increased target enhancing lesion diameter was a reason for progression in 8/86 cases (9.3%) but never the only radiologic or clinical reason. Event-free survival was predicted earlier...Continue Reading

References

May 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alba A BrandesMario Ermani
Nov 26, 2009·AJR. American Journal of Roentgenology·James M ProvenzaleDavid Delong
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Mar 27, 2013·Current Neurology and Neuroscience Reports·Olivier L ChinotTimothy F Cloughesy
Feb 21, 2014·The New England Journal of Medicine·Olivier L ChinotTimothy Cloughesy
Oct 15, 2014·Neuro-oncology·David A ReardonBenjamin M Ellingson
Aug 8, 2015·Neuro-oncology·Benjamin M EllingsonUNKNOWN Jumpstarting Brain Tumor Drug Development Coalition Imaging Standardization Steering Committee
Dec 25, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Karen A ManiasAndrew C Peet
Jan 22, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Benjamin M EllingsonTimothy F Cloughesy
Mar 30, 2017·Current Treatment Options in Neurology·Harpreet HyareJeremy Rees
May 18, 2017·Journal of Immunology Research·Domenico AquinoValeria Cuccarini
Aug 7, 2017·Neoplasia : an International Journal for Oncology Research·Jessica K R BoultSimon P Robinson
Feb 8, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jacques GrillGilles Vassal

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Citations

Jan 12, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel Rodriguez GutierrezTim Jaspan

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