Evaluation of the inclusion of a mixture of organic acids or lactulose into the feed of pigs experimentally challenged with Salmonella Typhimurium

Veterinary Microbiology
Sandra Martín-PeláezSusana M Martín-Orúe

Abstract

A mixture of organic acids and lactulose for preventing or reducing colonization of the gut by Salmonella Typhimurium was evaluated in pigs. A total of 63 4-week-old commercial piglets were randomly distributed into three different experimental dietary groups: a plain diet without additives (PD) and the same diet supplemented with either 0.4% (w/v) formic acid and 0.4% lactic acid (w/v) (AC) or 1% (w/v) lactulose (LC). After 7 days of adaptation, two-thirds of the pigs (14 from each diet) were challenged with a 2-mL oral dose of 10(8)CFU/mL of Salmonella Typhimurium, leaving the remaining animals unchallenged (UC). After 4 and 10 days post-challenge, pigs were euthanized and the ileum and caecum content were aseptically sampled to (a) quantify lactic, formic, and short-chain fatty acids (SCFA), (b) quantify bacterial populations and Salmonella by fluorescence in situ hybridization and (c) qualitatively analyse bacterial populations through denaturing gradient gel electrophoresis (DGGE). Modification of fermentation products and counts of some of the bacterial groups analysed in the challenged pigs receiving the treatments AC and LC were minimal. Treatments only influenced the bacterial diversity after 10 days post-challenge, wi...Continue Reading

References

Jan 5, 2006·Applied and Environmental Microbiology·I GantoisF Van Immerseel
Sep 27, 2007·Zoonoses and Public Health·E CreusE Mateu
Mar 12, 2009·Journal of Proteome Research·Alison WaldramJeremy K Nicholson

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Citations

Apr 9, 2011·International Journal of Food Microbiology·Michael P Doyle, Marilyn C Erickson
Mar 24, 2016·Risk Analysis : an Official Publication of the Society for Risk Analysis·Andrew A HillEmma L Snary
Jun 29, 2010·FEMS Microbiology Ecology·Eva Ogué-BonRobert A Rastall
Jun 8, 2014·Applied and Environmental Microbiology·A A Guerra-OrdazS M Martín-Orúe
Nov 7, 2012·Journal of Food Protection·Joris MichielsStefaan De Smet

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