Evaluation of the influence of chronic low-dose radiation on DNA repair gene polymorphisms [XRCC1 , XRCC3, PRKDC (XRCC7), LIG1 , NEIL1 ] in individuals from normal and high level natural radiation areas of Kerala Coast

International Journal of Radiation Biology
Divyalakshmi SainiBirajalaxmi Das

Abstract

Background: Single Nucleotide Polymorphisms (SNPs) at DNA repair genes are considered as potential biomarkers of radio-sensitivity. The coastal belt of Kerala in south west India has a patchy distribution of monazite in its beach sand that contains Th-232 and its decay products. Thus, radiation levels in this area vary from <1.0mGy to 45.0mGy/year. The areas with external gamma radiation dose >1.5mGy/year are considered as High-Level Natural Radiation Areas (HLNRA) and ≤ 1.5mGy/year are Normal Level Natural Radiation Area (NLNRA).Objective: In the present study, an attempt was made to evaluate the influence of chronic low dose radiation exposure on DNA repair gene polymorphisms in NLNRA and HLNRA population of Kerala coast.Materials and methods: Genomic DNA was isolated from venous blood samples of 246 random, healthy individuals (NLNRA, N = 104; HLNRA, N = 142) and genotyping of five SNPs such as X-ray repair cross complementing 1(XRCC1 Arg399Gln), X-ray repair cross complementing 3 (XRCC3 Thr241Met], Protein kinase, DNA-activated, catalytic subunit (PRKDC) (X-ray repair cross-complementing group 7, XRCC7 G/T), nei like DNA glycosylase 1 (NEIL1 G/T) and DNA ligase 1 (LIG1 A/C) was carried out using PCR based restriction fragme...Continue Reading

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Apr 22, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Shou-Yu WangQi-Zhan Liu
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiadong ZhaiQingyi Wei
Dec 11, 2008·Health Physics·Raghu Ram K NairTsutomu Sugahara
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Mar 21, 2018·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Karuppasamy C VBirajalaxmi Das

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