PMID: 976798Aug 1, 1976Paper

Evaluation of the intraepithelial lymphocyte count in the jejunum in childhood enteropathies

J MavromichalisC M Anderson


Intraepithelial lymphocyte counts were evaluated in 131 jejunal mucosal biopsies taken from children with a small intestinal enteropathy arising from a variety of causes including coeliac disease, (untreated, after gluten withdrawal, and during subsequent challenge), giardiasis, cow's milk protein intolerance, and 'intractable diarrhoea'. The counts were compared with those from the biopsies of children referred for investigation but in whom no gastrointestinal disease was demonstrated and from healthy siblings of children with coeliac disease, investigated during a family study. Children with coeliac disease showed a raised count which fell after gluten withdrawal as has been demonstrated by others in adults. Lymphocytic infiltration of the epithelium increased rapidly during gluten challenge in such children, while no change was seen in those children proven ultimately not to have coeliac disease by the usually recognized criteria. In other enteropathies the range of counts was wide, overlapping with both normal and coeliac groups and indicating the nonspecificity of lymphocytic infiltration of the gut epithelium. The findings are discussed in relation to their significance and to further avenues of investigation to determine...Continue Reading


May 1, 1980·European Journal of Pediatrics·M J Brueton
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M Bugaut
Jul 1, 1987·Baillière's Clinical Gastroenterology·J Spencer, P G Isaacson
Jan 1, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Robert M NajarianJeffrey D Goldsmith
Apr 2, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lorenzo MemeoGovind Bhagat
Jul 6, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Fuju ChangHarriet Deere
Aug 1, 1979·Archives of Disease in Childhood·J F GlasgowA Molla
Oct 1, 1977·Journal of Clinical Pathology·T CooneyM J Whelton
Apr 1, 1981·Journal of Clinical Pathology·F J PennaM Shiner
Aug 25, 2009·Advances in Anatomic Pathology·Susanne W CarmackRobert M Genta
Sep 24, 2011·Pathology, Research and Practice·Marjorie M Walker, Nicholas J Talley
May 10, 2015·Clinics and Research in Hepatology and Gastroenterology·Daniele SimondiMarco Astegiano
Nov 9, 2010·Histopathology·Marjorie M Walker, J A Murray
Jul 1, 1989·Acta paediatrica Scandinavica·L MagauddaG Magazzù
Sep 23, 2003·The American Journal of Gastroenterology·Sanjay KakarLawrence J Burgart
Jan 1, 1978·Gut·M Ponz De LeonR H Dowling
Dec 1, 1979·CRC Critical Reviews in Clinical Laboratory Sciences·S B Taubman
Jan 1, 1990·Springer Seminars in Immunopathology·A M Mowat
Sep 15, 2020·Journal of Pediatric Gastroenterology and Nutrition·Janaki DevaraImad Absah

Related Concepts

Celiac Disease
Intestinal Diseases
Structure of Intestinal Gland
Lactose Intolerance
Differential White Blood Cell Count Procedure

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.