Evaluation of the ischemic protection efficacy of a laparoscopic renal cooling device using renal transplantation viability assessment criteria in a porcine model

The Journal of Urology
A P NavarroN A Soomro

Abstract

We assessed the efficacy of a prototype laparoscopic topical cooling device. The aim of regional renal hypothermia in laparoscopic surgery is to limit ischemic injury and extend safe operative time. A reliable model for assessing renal ischemic injury exists in the field of nonheart beating donor renal transplantation. Hypothermic machine perfusion allows calculation of the pressure flow index and measurement of glutathione S-transferase in the perfusate. These parameters allow accurate assessment of the extent of renal damage. The device incorporates a 2-layer cooling bag and coolant circuit. The system achieves hypothermia by circulating coolant across the surface of the kidney. Using 10 pigs individual kidneys were subjected to periods of renal ischemia with or without device in situ cooling. Each kidney was then machine perfused and assessed using nonheart beating donor viability criteria. The best performance of the device achieved a renal parenchymal temperature of 15C in 11.2 minutes (mean +/- SD 21.4 +/- 8.42). In the warm ischemia groups significant deterioration of pressure flow index compared to controls occurred by 60 minutes (p = 0.0001). In cooled kidneys at 60 minutes the mean pressure flow index was not signific...Continue Reading

References

Dec 1, 1967·British Journal of Urology·J E WickhamA M Joekes
May 20, 1999·The Journal of Urology·C C AbbouL Salomon
May 8, 2002·Der Urologe. Ausg. A·G JanetschekK Leeb
Mar 27, 2003·BJU International·A El-GhoneimiA Khoury
Apr 2, 2003·Current Oncology Reports·Scott M GilbertJames M McKiernan
Jun 11, 2003·The Journal of Urology·Inderbir S GillJihad H Kaouk
Jun 11, 2003·The Journal of Urology·Inderbir S GillAndrew C Novick
Dec 11, 2003·The Journal of Urology·Günter JanetschekManfred Gschwendtner
Nov 11, 2006·BJU International·Brett A LavenArieh L Shalhav

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Citations

Aug 5, 2008·Medical & Biological Engineering & Computing·E S ColechinC Griffiths
Jan 17, 2012·Transplantation·Ugo BoggiFranco Mosca
Jan 9, 2013·Transplantation·E R Pieter HooglandL W Ernest van Heurn
Jul 2, 2011·The Review of Diabetic Studies : RDS·Ugo BoggiFranco Mosca
Feb 18, 2016·Kidney International·Karthik K TennankoreBryce A Kiberd
Nov 26, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Ugo BoggiFranco Mosca
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Omar TujjarFabio Silvio Taccone
May 19, 2018·Journal of Endourology·Sohrab Arora, Craig Rogers

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