Evaluation of the Langat/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteers.

Vaccine
Peter F WrightAlexander G Pletnev

Abstract

With the steady rise in tick-borne encephalitis virus (TBEV) infections in Europe, development of a live attenuated vaccine that will generate long-lasting immunity would be of considerable benefit. A chimeric flavivirus, designated LGT/DEN4, was previously constructed to have a genome containing the prM and E protein genes of Langat virus (LGT), a naturally attenuated member of the TBEV complex, and the remaining genetic sequences derived from dengue 4 virus (DEN4). LGT/DEN4 was highly attenuated in rodents and non-human primates, and clinical trials in humans were initiated. Twenty-eight healthy seronegative adult volunteers were randomly assigned in a 4:1 ratio to receive 10(3) plaque-forming units (PFU) of LGT/DEN4 or placebo. Volunteers were closely monitored for clinical responses and for blood chemistry and hematological changes, and the level of viremia and the magnitude and duration of the neutralizing antibody response were determined. The LGT/DEN4 vaccine was safe and viremia was seen in only one vaccinee. Infection induced a neutralizing antibody response to wild-type LGT in 80% of volunteers with a geometric mean titer (GMT) of 1:63 present on day 42 post-immunization; however the antibody response against TBEV was...Continue Reading

References

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Citations

Jun 8, 2014·Ticks and Tick-borne Diseases·Rafidah LaniKeivan Zandi
Mar 21, 2008·Journal of Virology·Olga A MaximovaAlexander G Pletnev
Dec 15, 2010·Vector Borne and Zoonotic Diseases·Amber R EngelAlexander G Pletnev
Aug 22, 2009·Journal of Medical Virology·Natalia S PripuzovaGalina G Karganova
Jul 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Alexander A RumyantsevKonstantin V Pugachev
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Vittorio DemicheliAlessandro Rivetti
Aug 25, 2012·Uirusu·Tomohiro Ishikawa, Eiji Konishi
Nov 11, 2014·Expert Review of Vaccines·Mark A Mogler, Kurt I Kamrud
Aug 19, 2020·Vaccines·Mareike KubinskiGuus F Rimmelzwaan

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