Evaluation of the long-lasting antihypertensive action of 7-O-ethylfangchinoline

Japanese Journal of Pharmacology
T KatoM Sakanashi


The antihypertensive effect of 7-O-ethylfangchinoline (TJN-220) was analyzed in an experimental model of hypertensive rats under the conscious condition. Single oral administration of TJN-220 (25 and 50 mg/kg) produced a progressive and long-lasting fall of mean blood pressure in spontaneously hypertensive rats (SHRs), deoxycorticosterone acetate (DOCA)-salt hypertensive rats and renal hypertensive rats until 72 hr after the drug administration, but affected neither the heart rate in these hypertensive rats nor the hemodynamic parameters in normotensive rats. In SHRs implanted with a telemetry transmitter, TJN-220 (50 mg/kg, p.o.) produced falls of systolic and diastolic blood pressures and diminished the difference in blood pressure between the dark period and the light period for 3 days, particularly by suppressing the increasing phase of blood pressure during the dark period without influencing heart rate or locomotor activity. On the other hand, nicardipine (10 mg/kg, p.o.) produced a transient fall of blood pressure associated with a tachycardia during the light period on the first day alone. Clonidine (0.3 mg/kg, p.o.) diminished the increasing phases of blood pressure and heart rate during the dark period on the first da...Continue Reading


Dec 1, 1979·Clinical Science·S MannE B Raftery
Nov 1, 1977·Clinical Pharmacology and Therapeutics·M GuazziP Moruzzi
Jan 1, 1991·General Pharmacology·K KawashimaZ X Chen
Sep 1, 1989·Japanese Journal of Pharmacology·K OizumiT Kimura
Nov 1, 1993·Cardiovascular Research·M C Sutter, Y X Wang

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