PMID: 11900960Mar 20, 2002Paper

Evaluation of the long-term immune response in cattle after vaccination against paratuberculosis in two Dutch dairy herds

Veterinary Microbiology
J MuskensD Bakker

Abstract

In the past decades, vaccination against paratuberculosis in cattle was performed in The Netherlands only on a limited scale. Because of its interference with the diagnosis of bovine tuberculosis, vaccination was restricted to herds with a high prevalence of clinical cases of paratuberculosis and was meant to aid in the economical survival of the farm. Recently, a voluntary paratuberculosis certification program has started, based in part on serological screening of cattle of at least 3 years of age. Herds that have been vaccinated against paratuberculosis are, therefore, likely to encounter problems when entering this program. The aim of this study was to evaluate the immune response resulting from vaccination with a heat-killed paratuberculosis vaccine. Over a period of 12-14 years, new-born calves were vaccinated in two herds. The B-cell response was evaluated using both the complement-fixation test (CFT) and an enzyme-linked immunosorbent assay (ELISA) and the cell-mediated immune response was evaluated using the gamma-interferon assay. Data obtained show a marked and prolonged effect of the vaccination on both cellular and humoral immune responses, in particular to the paratuberculosis antigen but also to the bovine tuberc...Continue Reading

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Citations

May 12, 2005·Veterinary Immunology and Immunopathology·Anne K StorsetBerit Djønne
Dec 3, 2013·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Ana JollySilvia Leonor Mundo
Nov 15, 2011·The Veterinary Quarterly·Wiebren SantemaAd Koets
Dec 25, 2012·Research in Veterinary Science·T CartaC Gortázar
Dec 23, 2011·Veterinary Immunology and Immunopathology·Vibeke Thulstrup ThomsenGregers Jungersen
Oct 26, 2011·The Veterinary Clinics of North America. Food Animal Practice·Elisabeth A Patton
Sep 13, 2011·The Veterinary Journal·Christophe ChartierJaquemine Vialard
Sep 27, 2008·Preventive Veterinary Medicine·Søren Saxmose Nielsen, Nils Toft
Jul 17, 2003·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·J MuskensD Bakker
Feb 6, 2007·Veterinary Immunology and Immunopathology·A J NedrowM L Thonney
Sep 25, 2014·Frontiers in Cellular and Infection Microbiology·John P BannantineVivek Kapur
Jul 28, 2016·Epidemiology and Infection·J M BroughanS H Downs
Nov 4, 2016·Clinical and Vaccine Immunology : CVI·Daniel C ShippyAdel M Talaat
Aug 5, 2016·Clinical and Experimental Vaccine Research·Hong-Tae Park, Han Sang Yoo
Jul 31, 2008·Expert Review of Vaccines·Valérie Rosseels, Kris Huygen
May 16, 2009·Expert Opinion on Therapeutic Patents·J R Keeble, K B Walker
Sep 23, 2020·Microorganisms·Yashdeep PhanseAdel M Talaat

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