Evaluation of the microcirculatory disturbance of biliary ischemia after liver transplantation with contrast-enhanced ultrasound: preliminary experience

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Jie RenYan Lu

Abstract

The aim of this study was to determine the efficacy of contrast-enhanced ultrasound for depicting the perfusion of hilar bile ducts in ischemic-type biliary lesions after orthotopic liver transplantation. Thirteen transplant recipients with ischemic-type biliary lesions and 12 patients without ischemic-type biliary lesions underwent ultrasound examinations after the injection of 1.5 mL of an intravenous contrast agent. The enhancement of the hilar bile duct wall in the arterial, portal venous, and late phases was qualitatively graded as higher, equal, lower, or none with respect to that of the adjacent liver parenchyma. No or low contrast enhancement was seen in 10 of 13 patients (76.90%) with biliary ischemia, whereas increased contrast enhancement with respect to the normal liver parenchyma was found in all 12 patients without biliary ischemia. The difference in the enhancement patterns between the 2 groups was significant (P = 0.0001). In conclusion, contrast-enhanced ultrasound is a new imaging modality to depict perfusion of the hilar bile duct. No or low contrast enhancement of the bile duct wall in the arterial phase may reflect the microcirculatory disturbance of biliary ischemia and may contribute to its early diagnosis.

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Citations

Jul 3, 2013·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Ahmed AlzaraaDavid Lloyd
Feb 11, 2012·Annals of Surgery·Juliette C SliekerGeert Kazemier
Nov 28, 2012·World Journal of Gastroenterology : WJG·Xin-Hua ZhuYi-Tao Ding
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Mar 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W R R FaridG Kazemier
Jul 12, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Waqar R R FaridGeert Kazemier
Jun 8, 2013·Journal of Clinical Ultrasound : JCU·Teresa FontanillaElisa Aguirre
Apr 2, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sunil DachaJosh Levitsky
Jan 29, 2016·World Journal of Gastroenterology : WJG·Jie RenGui-Hua Chen
Oct 10, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Romina MancinelliEugenio Gaudio
Dec 4, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Bo-Wen ZhengJie Ren

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