PMID: 8584984Jan 1, 1995Paper

Evaluation of the modifying influence of arecanut on the garlic-modulated hepatic detoxication system enzymes, sulfhydryl content, and lipid peroxidation in mice

Teratogenesis, Carcinogenesis, and Mutagenesis
A Singh, A R Rao

Abstract

This paper evaluates the potential effects of arecanut (Areca catechu, L.), an important ingredient of betel quid, on the garlic (Allium sativum, L.)-modulated activities of hepatic detoxication system enzymes, acid soluble sulfhydryl content, and lipid peroxidation in mice. Mice were fed on either a normal diet or a diet containing 0.25%, 0.5%, or 1% (w/w) arecanut for 45 days. During the last 10 days of treatment oral administration of garlic at the dose level of 20 or 100 mg/kg body weight/day was supplemented. Significant modulation in the activities of phase I and phase II enzymes, -SH content, and malondialdehyde (MDA) level by garlic was observed. Garlic-modulated alterations in glutathione S-transferase (GST) activity and -SH content were decreased, while cytochrome b5, cytochrome P-450, and MDA levels were further augmented by the arecanut plus garlic treatments.

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Citations

Sep 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A SinghR Bamezai
Aug 2, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Mamdouh M Anwar, Abdel-Raheim M A Meki
Dec 27, 1996·Annals of the New York Academy of Sciences·R A Roberts
Mar 20, 2021·The Journal of Pharmacy and Pharmacology·Nadire EserMustafa Cicek

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