Evaluation of the neuropharmacodynamics of paroxetine in vivo utilizing microdialysis

Journal of Pharmaceutical Sciences
A RamaiyaH T Karnes

Abstract

The effect of paroxetine, a selective serotonin reuptake inhibitor used in the treatment of depression, on extracellular serotonin levels was evaluated in freely moving conscious rats. Microdialysis, a powerful in vivo technique to monitor the extracellular levels of neurotransmitters, was used to monitor the baseline changes in the levels of serotonin in rat brain anterior lateral striatum post paroxetine administration, which is a measure of the neuropharmacodynamic effect of the drug. Microdialysis sampling was performed for 210 min prior to and for 240 min after intraperitoneal administration of paroxetine (10 mg/kg). Paroxetine caused a statistically significant increase in the extracellular levels of serotonin in the anterior lateral striatum sampled by microdialysis. The present study demonstrates the utility of microdialysis for studying the in vivo neuropharmacodynamics of paroxetine in conscious rats.

References

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Mar 28, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·A Ramaiya, H T Karnes

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Citations

Jul 29, 1999·Biomedical Chromatography : BMC·C S Chaurasia
Mar 22, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·Fevziye Toros, Kubilay Erdoğan
Oct 7, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kensuke OritoMichihiro Fujiwara
Apr 29, 2004·Clinical EEG and Neuroscience·Phillip C Jobe
Feb 17, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew MazalouskasAna M D Carneiro

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