Evaluation of the passive particle agglutination test in the serodiagnosis and follow-up of syphilis

American Journal of Clinical Pathology
Rita CastroFilomena da L Exposto

Abstract

We performed the present study to determine the rate of concordance of the fluorescent treponemal antibody absorption test (FTA-ABS) and of the microhemagglutination assay for antibodies to Treponema pallidum (MHA-TP) with the passive particle agglutination test (TP.PA) in patients with early syphilis and to observe the reactivity of the rapid plasma reagin (RPR), MHA-TP, and the TP.PA tests for 1 year after therapy. The study included 449 people who were given therapy if they had syphilis and followed up for 1 year. The rate of concordance of the TP.PA with the MHA-TP was 98.4%, and it was 98.9% with the FTA-ABS. During follow-up, a significant decrease of antibodies was found in 56%, 26%, and 70% of the patients when using the RPR, the MHA-TP, and the TP.PA, respectively. The TP.PA seems to be an adequate routine assay for the diagnosis of syphilis, being as sensitive as the FTA-ABS test in primary syphilis and as useful as the RPR test in monitoring therapy.

References

Aug 1, 1978·American Journal of Clinical Pathology·H W JaffeP E Dans
Jun 15, 1991·Annals of Internal Medicine·B RomanowskiE J Love
Mar 1, 1985·JAMA : the Journal of the American Medical Association·S T BrownG H Reynolds
Jul 31, 1972·JAMA : the Journal of the American Medical Association·A L SchroeterV H Falcone
Nov 7, 1966·JAMA : the Journal of the American Medical Association·W E DeaconE V Price
Jun 27, 1980·JAMA : the Journal of the American Medical Association·N J Fiumara
Jan 1, 1995·Clinical Microbiology Reviews·S A LarsenA H Rudolph
Oct 1, 1994·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·M DeguchiS Asari

❮ Previous
Next ❯

Citations

Jul 25, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M J ColeJ V Parry
Dec 3, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Nobuyasu YukimasaKunihiko Fukuchi
Oct 21, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·F DragoA Parodi
Nov 23, 2006·Journal of Clinical Laboratory Analysis·Rita CastroFilomena da L Exposto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.