Evaluation of the penetration of 5-aminolevulinic acid through basal cell carcinoma: a pilot study

Experimental Dermatology
Sharareh AhmadiK McKenna

Abstract

Aminolevulinic acid (ALA) is a charged, hydrophilic molecule that penetrates poorly through cellular structures. This property has been implicated in the poor clinical response of non-superficial basal cell carcinomas (BCCs) to photodynamic therapy (PDT). Release of ALA hydrochloride from a 20% w/w formulation was found to be incomplete and that approximately 36.8% of the total dose is released during the application period of 4 h. Using scintillation spectroscopy and a precise tissue sectioning protocol, it was demonstrated that depths of penetration of at least 2 mm from the lesion surface had been reached. Using cumulative stratal ALA concentrations, it was found that 10% of the total applied dose permeated into the lesion. In spite of this, comparisons drawn with photodynamic concentrations used in tissue culture work reported elsewhere revealed that estimations of the ALA concentration at 2 mm were sufficient to elicit a possible therapeutic response. Results from this work question the reasons given for poor outcomes of PDT in nodular BCC based solely on depth as a hindering factor.

References

Aug 31, 1992·Journal of Photochemistry and Photobiology. B, Biology·B A GoffT Hasan
Jun 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·J C KennedyD C Pross
Nov 1, 1996·The British Journal of Dermatology·C A MortonR M Mackie
Jan 6, 1997·International Journal of Cancer. Journal International Du Cancer·J MoanK Berg
Mar 6, 1998·Archives of Dermatology·C FritschT Ruzicka
Aug 7, 1998·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Y HarthB Kaplan
Nov 13, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·A F HürlimannR G Panizzon
Nov 9, 2000·The British Journal of Dermatology·C A MortonR M MacKie
Apr 3, 2001·International Journal of Cancer. Journal International Du Cancer·J MoanV Iani
Sep 5, 2001·The British Journal of Dermatology·T Markham, P Collins
Sep 22, 2001·Journal of Photochemistry and Photobiology. B, Biology·Q PengK E Giercksky
Feb 15, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·A T DijkstraW A van Vloten
Feb 18, 2003·The British Journal of Dermatology·G SaldanhaD N Slater

❮ Previous
Next ❯

Citations

Nov 4, 2008·Archives of Dermatological Research·Susanne NeusPercy Lehmann
Jan 15, 2009·Photochemistry and Photobiology·Petras JuzenasJohan Moan
May 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sanjay AnandEdward V Maytin
Jun 27, 2012·Expert Opinion on Drug Delivery·Nina Dragicevic-Curic, Alfred Fahr
Oct 7, 2005·Drug Development and Industrial Pharmacy·Toshiyuki KosobeNorimichi Kawashima
Sep 18, 2012·Journal of the American Academy of Dermatology·Manuel Ángel Rodríguez-PrietoIgnacio García Doval
Sep 27, 2008·Journal of Photochemistry and Photobiology. B, Biology·Nora DögnitzGeorges Wagnières
Oct 27, 2007·Journal of Photochemistry and Photobiology. B, Biology·Ryan F DonnellyA David Woolfson
Sep 1, 2007·Photodiagnosis and Photodynamic Therapy·Peter SchleierStefan Schultze-Mosgau
Mar 21, 2008·Photodermatology, Photoimmunology & Photomedicine·Thilo GambichlerPeter Altmeyer
Sep 23, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·E ChristensenS Sundstrøm
Jun 20, 2008·Lasers in Surgery and Medicine·Christian S BetzColin Hopper
Oct 24, 2008·The British Journal of Dermatology·C A MortonUNKNOWN British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and the British Photodermatology Group
Sep 1, 2006·Photodiagnosis and Photodynamic Therapy·Ryan F DonnellyJohan Moan
May 10, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Brendan F GilmoreRyan F Donnelly
Dec 7, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Paul A McCarronA David Woolfson
Aug 21, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit K JainHarvinder S Gill
Sep 21, 2016·Photodiagnosis and Photodynamic Therapy·María Jesús Suárez-ValladaresRicard Serra-Llusà
Jul 16, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·Patrick GholamAlexander Enk
Jun 21, 2005·Lasers in Surgery and Medicine·Ahmad KavianiGholamreza Esmaeeli Djavid
May 6, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Hui XuZhi-Qiang Chen
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea Jess JosiahNamrita Lall

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.