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Evaluation of the permanent sympathectomy produced by the administration of guanethidine to adult rats

The Journal of Pharmacology and Experimental Therapeutics

Jan 1, 1976

Eric F Johnson, F O'Brien

PMID: 1517

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Abstract

The administration of guanethidine to adult rats has been shown by morphological criteria to destroy sympathetic neurons. The objective of this study was to evaluate by biochemical and functional criteria the degree and permanence of this sympathectomy. Young adult male rats (260-300 g)...read more

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Vas Deferens Structure
Smooth Muscle
Intestines
Nerve-Muscle Preparation
Guanethidine
Norepinephrine
TH gene
Ganglia, Spinal
Entire Sympathetic Nervous System
Intestines, Small
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  • Evaluation of the permanent sympathectomy produced by the administration of guanethidine to adult rats

    The Journal of Pharmacology and Experimental Therapeutics

    Jan 1, 1976

    Eric F Johnson, F O'Brien

    PMID: 1517

    DOI:

    Abstract

    The administration of guanethidine to adult rats has been shown by morphological criteria to destroy sympathetic neurons. The objective of this study was to evaluate by biochemical and functional criteria the degree and permanence of this sympathectomy. Young adult male rats (260-300 g)...read more

    Mentioned in this Paper

    Vas Deferens Structure
    Smooth Muscle
    Intestines
    Nerve-Muscle Preparation
    Guanethidine

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