Abstract
The high incidence of BB2 receptor (BB2r) expression in various cancers has prompted investigators to pursue the development of BB2r-targeted agents for diagnostic imaging, chemotherapy, and radiotherapy. Development of BB2r-targeted agents, based on the bombesin (BBN) peptide, has largely involved the use of the bifunctional chelate approach in which the linking group serves several key roles including pharmacokinetic modification. Understanding the in vivo properties of the various pharmacokinetic modifying linking groups is crucial for developing BB2r-targeted agents with improved targeting and clearance characteristics. The goal of this study was to systematically evaluate the pharmacokinetic profile of aliphatic hydrocarbon, aromatic, and poly(ethylene glycol) (ether) functional groups in order to obtain a better understanding of the in vivo properties of these pharmacokinetic modifiers. Specifically, we synthesized six radioconjugates with the structure 111In-DOTA- X-BBN(7-14)NH2, where X = 8-aminooctanoic acid (8-AOC), 5-amino-3-oxapentyl-succinamic acid (5-ADS), 8-amino-3,6-dioxaoctyl-succinamic acid (8-AOS), p-aminobenzoic acid (AMBA), Gly-AMBA, and Gly- p-aminomethylbenzoic acid (Gly-AM2BA). All of the (nat)In-conjuga...Continue Reading
References
Jan 15, 1998·Nuclear Medicine and Biology·P M Smith-JonesC Bruns
Dec 14, 1999·The American Journal of Pathology·M Gugger, J C Reubi
Feb 15, 2001·Bioconjugate Chemistry·S Liu, D S Edwards
Dec 26, 2001·Chemical Reviews·C J Anderson, M J Welch
Dec 26, 2001·Chemical Reviews·W A Volkert, T J Hoffman
May 29, 2002·Nuclear Medicine and Biology·Fang HuSilvia S Jurisson
Jan 16, 2003·Bioconjugate Chemistry·C Jeffrey SmithTimothy J Hoffman
Mar 8, 2003·Nuclear Medicine and Biology·C Jeffrey SmithTimothy J Hoffman
Apr 18, 2003·Cancer Immunology, Immunotherapy : CII·Pamela A TrailGene M Dubowchik
Dec 31, 2003·Nuclear Medicine and Biology·C J SmithT J Hoffman
May 27, 2004·Radiation Research·Bieke LambertAndreas Otte
Sep 18, 2004·Cancer Research·Hanwen ZhangHelmut R Maecke
Oct 26, 2005·Nuclear Medicine and Biology·Charles J SmithTimothy J Hoffman
Feb 7, 2006·Nuclear Medicine and Biology·Moustapha E MoustaphaSilvia S Jurisson
May 19, 2006·Cancer Biotherapy & Radiopharmaceuticals·Christopher V JohnsonTimothy J Hoffman
Aug 16, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Beatrice WaserJean Claude Reubi
Jan 31, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Hanwen ZhangHelmut R Maecke
Mar 14, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D B CornelioG Schwartsmann
Jul 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Adam F PrasanphanichCharles J Smith
Jul 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jered C GarrisonTimothy J Hoffman
Dec 7, 2007·Pharmacological Reviews·R T JensenR V Benya
Citations
Mar 6, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Melpomeni Fani, Helmut R Maecke
Feb 3, 2012·Bioconjugate Chemistry·Nilesh K WaghJered C Garrison
Jun 15, 2010·Bioconjugate Chemistry·Zhaofei LiuXiaoyuan Chen
Apr 27, 2010·Chemical Reviews·Thaddeus J WadasCarolyn J Anderson
Jun 30, 2011·Cancer Biotherapy & Radiopharmaceuticals·Seyed Pezhman ShirmardiMojtaba Shamsaei
Oct 2, 2012·PloS One·Hanwen ZhangHelmut R Maecke
Mar 23, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Haixun GuoYubin Miao
Mar 8, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Ajay ShrivastavaMichael F Tweedle
Mar 25, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Rogier P J SchroederM de Jong
Jun 11, 2011·Journal of Biomedicine & Biotechnology·Chung-Li HoChih-Hsien Chang
Jan 6, 2015·Amino Acids·Jianquan YangYubin Miao
Mar 13, 2012·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·P B PujattiE B de Araújo
Aug 3, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Lucia TorneselloFranco Maria Buonaguro
Jan 1, 2020·Anti-cancer Agents in Medicinal Chemistry·Arezou M FarahaniNourollah Sadeghzadeh
Feb 4, 2021·Journal of Medicinal Chemistry·Rajendra P BandariCharles J Smith
Dec 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nurmaya EffendiKazuma Ogawa
Mar 7, 2021·Pharmaceuticals·Mária Bodnár Mikulová, Peter Mikuš
Apr 7, 2009·Bioconjugate Chemistry·Eirini A FragogeorgiSpyridon C Archimandritis
Dec 3, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Haixun Guo, Yubin Miao
Oct 12, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wenting ZhangJered C Garrison
Jul 31, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Zhengyuan ZhouJered C Garrison
Jun 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Zhaofei LiuXiaoyuan Chen
Nov 8, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yang LiuZhen Cheng
Jan 29, 2009·Bioconjugate Chemistry·Stefanie JuranPeter Comba
Dec 31, 2008·Journal of Medicinal Chemistry·Zhaofei LiuXiaoyuan Chen
Sep 4, 2010·Bioconjugate Chemistry·Joeri KuilFijs W B van Leeuwen
Nov 1, 2018·Chemical Reviews·Thomas I Kostelnik, Chris Orvig
Aug 17, 2018·Journal of Medicinal Chemistry·Hang XuLixin Ma
Oct 11, 2011·Nuclear Medicine and Biology·Simone DäppRoger Schibli