Abstract
Hydroxycitric acid (HCA), the main compound of Garcinia cambogia extract, is a competitive blocker of ATP-citrate-lyase, presenting a potential inhibition of fatty acid biosynthesis. Glucomannan fibers, abundant in Amorphophallus konjac, seem to reduce the absorption kinetics of dietary fat. Therefore, the aim of this double-blind randomized study was to evaluate the pharmacotherapeutic efficacy of standardized extracts of G. cambogia (52.4% HCA) plus A. konjac (94.9% glucomannan) in the treatment of obesity. Fifty-eight obese subjects (BMI 30.0-39.9 kg/m(2)) were assigned to the placebo group (n = 26) or the treatment group (n = 32); no dietary restrictions were applied. Over a 12-week period, subjects were given daily doses of either Garcinia (2.4 g) plus Konjac (1.5 g) or placebo prior to their main meals (3 times/day). Before the start of treatment, and every 4 weeks thereafter, the following were recorded: height, weight, circumferences and body composition, resting energy expenditure (REE), lipid profile and glucose levels. The treatment had no significant effect on anthropometric parameters, REE, triglycerides or glucose levels. However, a significant reduction was observed in total cholesterol (-32.0 +/- 35.1 mg/dL) and...Continue Reading
References
Oct 1, 1978·The American Journal of Clinical Nutrition·M A Eastwood
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Feb 1, 1992·The American Journal of Clinical Nutrition·M A Eastwood, E R Morris
Sep 1, 1984·Culture, Medicine and Psychiatry·S D Minuchin-ItzigsohnD Krasilowsky
Apr 1, 1983·Circulation·W P CastelliP M McNamara
Mar 1, 1995·The American Journal of Clinical Nutrition·A Arvill, L Bodin
Nov 20, 1998·JAMA : the Journal of the American Medical Association·S B HeymsfieldC Nunez
Jun 18, 1999·Diabetes Care·V VuksanC Bruce-Thompson
Dec 9, 2000·The Journal of Nutrition·K IshiharaT Fushiki
Jan 3, 2001·Physiology & Behavior·R D Mattes, L Bormann
Dec 18, 2001·Experimental Biology and Medicine·P J Havel
Jan 17, 2002·European Heart Journal·J SimesJ Shepherd
Jan 17, 2003·Obesity Research·Christopher I ArdernRobert Ross
Feb 6, 2003·Journal of the American College of Nutrition·Hsiao-Ling ChenYi-Chuan Chen
May 3, 2003·Fitoterapia·K HayamizuM Furuse
Jan 9, 2004·Endocrinology and Metabolism Clinics of North America·Barbara V HowardDavid C Robbins
Apr 20, 2004·Obesity Research·Shankuan ZhuSteven B Heymsfield
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·George A Bray
Jul 28, 2004·Diabetes·Darcy B CarrSteven E Kahn
Aug 1, 1949·The Journal of Physiology·J B DE B WEIR
Oct 12, 2004·Clinics in Dermatology·Victor J Lawrence, Peter G Kopelman
Citations
Nov 10, 2009·Plant Cell Reports·Huifang BanMing Sun
May 15, 2013·Plant Foods for Human Nutrition·Katie J AstellXiao Q Su
Jul 24, 2013·Complementary Therapies in Medicine·Katie J AstellXiao Q Su
Apr 26, 2012·Critical Reviews in Food Science and Nutrition·Fabiola MárquezJ Salas-Salvadó
Jan 5, 2011·Journal of Obesity·Igho OnakpoyaEdzard Ernst
Jul 28, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N D YulianaR Verpoorte
Oct 18, 2013·Phytotherapy Research : PTR·Carlos A R VasquesSimone Rossetto
Feb 24, 2015·Nutrition·Bartłomiej M ZalewskiHania Szajewska
Aug 28, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Li Oon ChuahNoorjahan Banu Alitheen
Aug 31, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Li Oon ChuahSwee Keong Yeap
Mar 4, 2015·Fitoterapia·Ruchi Badoni SemwalAlvaro Viljoen
Apr 22, 2015·International Journal of Endocrinology and Metabolism·Alireza EsteghamatiSina Noshad
Jul 20, 2014·Carbohydrate Polymers·Zhidong XiongZhiguo Su
Feb 19, 2014·Journal of the American College of Nutrition·Igho OnakpoyaEdzard Ernst
Aug 3, 2016·International Journal of Biological Macromolecules·Sudhanshu S Behera, Ramesh C Ray
Mar 2, 2017·Journal of Agricultural and Food Chemistry·Belén GómezJosé L Alonso
Jan 19, 2010·Journal of Ethnopharmacology·Melinda ChuaKelvin Chan
Apr 19, 2015·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Gerard E Mullin
Sep 29, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kavita PoddarLawrence J Cheskin
Jan 26, 2013·American Journal of Botany·Melinda ChuaTimothy C Baldwin
Jan 25, 2018·BMC Complementary and Alternative Medicine·Andrea Maia-LandimJosé L Lancho
Oct 1, 2019·Journal of Applied Microbiology·J P WuF L Guo
Jan 28, 2020·Diabetes, Obesity & Metabolism·Alison MaunderNicholas R Fuller
Jun 7, 2017·World Journal of Microbiology & Biotechnology·Jinping WuZhengming Qiu
Sep 20, 2019·Nutrients·Johann StubyJakob M Burgstaller
Feb 26, 2016·Lipids in Health and Disease·Jing HanHaitian Ma
Apr 24, 2019·International Journal of Molecular Sciences·Miaomiao SunLu Zheng
Dec 4, 2019·Phytotherapy Research : PTR·Moloud PayabBagher Larijani
Apr 26, 2020·Nutrients·Simona BoNicoletta Pellegrini
Feb 13, 2021·Nutrients·Naroa AnduezaMaria P Portillo
Jul 27, 2021·Frontiers in Microbiology·Fei He