Evaluation of the post-transfusion platelet increment and safety of riboflavin-based pathogen reduction technology (PRT) treated platelet products stored in platelet additive solution for 5 days or less versus 6-7 days

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Alesia KaplanMaria Luisa Antelo

Abstract

Platelets are stored routinely for 5 days or less and extended platelet storage time could improve product availability. This study compared platelet count increments (CI24hs) of riboflavin plus UV-light (PRT) treated platelet products in platelet additive solution stored for 5 days or less to products stored for 6-7 days. This was a retrospective study comparing CI24hs between two groups. Hematology patients received PRT treated platelet products stored for <5 days, or for 6-7 days. Platelet counts and adverse events during and up to 24 hours after transfusion were recorded and compared between the groups. Ninety-seven patients received 168 transfusions of <5 day old PRT-treated platelets and 49 patients received 74 transfusions of 6-7 day old PRT-treated platelets. There was no statistically significant difference in CI24hs between the <5 day (median 6000) and 6-7 day storage group (median 8000) (p-value = 0.509). One mild fever was documented in the <5 day storage group. CI24hs are similar for PRT-treated PLTs stored in PAS for <5 or 6-7 days. Studies to further evaluate clinical outcomes such as bleeding are ongoing.

References

Apr 2, 2003·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Roger Y Dodd
May 7, 2003·Transfusion Medicine Reviews·Steven KleinmanPierre Robillard
Jun 10, 2010·Transfusion·Susanne MarschnerRaymond P Goodrich
Jul 23, 2011·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Susanne Marschner, Raymond Goodrich
Mar 9, 2012·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Ana AntićMarija Jelić
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Sep 26, 2014·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Peter Schlenke

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Citations

Sep 11, 2019·Transfusion·Fabienne M A van HoutJohanna G van der Bom
Aug 6, 2018·Critical Care : the Official Journal of the Critical Care Forum·Cécile AubronZoe McQuilten

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