Evaluation of the potential immunotoxicity of 3-monochloro-1,2-propanediol in Balb/c mice. I. Effect on antibody forming cell, mitogen-stimulated lymphocyte proliferation, splenic subset, and natural killer cell activity

Toxicology
Jong Kwon LeeHye Young Oh

Abstract

3-Monochloro-1,2-propanediol (MCPD) is a well-known by-product of acid-hydrolyzed soy sauce during its manufacturing process. MCPD has been reported genotoxic in vitro, and reproductive toxicity and carcinogenicity in rats. However, no previous studies have investigated MCPD-induced alterations in the immune system. In the present study, MCPD was administered by gavage for 14 days at 0, 25, 50, and 100 mg/kg per day to female Balb/c mice. The antibody-mediated immune response to sheep red blood cells (SRBC) was assessed using the antibody-forming cell (AFC) assay, and splenic cell phenotypes were quantified by flow cytometry. Hematological and histopathological changes were assessed. Mitogen-stimulated spleen lymphocyte proliferation and natural killer (NK) cell activity were evaluated. The T-lymphocyte blastogenesis by concanavalin A (Con A) or anti-CD3 and B-lymphocyte blastogenesis by lipopolysaccharide (LPS) were not significantly changed. There were no significant changes in the hematological and histopathological findings of MCPD-treated mice. However, the significant decrease in thymus weight was observed in 100 mg dose group, even though that did not change body weight gain. The cellularities of spleen and thymus were s...Continue Reading

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Citations

Nov 1, 2005·Expert Review of Clinical Immunology·Jacques Descotes, Guillaume Ravel
Oct 6, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Byoung-Seok LeeHwa-Young Son
Aug 6, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wan-Seob ChoDong Deuk Jang
Aug 27, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jung A ByunJong Kwon Lee
Jun 12, 2013·Pharmaceutical Biology·Ishrina RubabShakir Ali
Mar 11, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wan-Seob ChoDong Deuk Jang
Jul 16, 2013·International Immunopharmacology·Jing LuShuang Guan
Jul 27, 2007·Journal of Toxicology and Environmental Health. Part a·Hyung Soo KimKui Lea Park
Jan 11, 2017·The Journal of Toxicological Sciences·Jian JiXiulan Sun
Jan 1, 2015·Comprehensive Reviews in Food Science and Food Safety·Bai Qin Lee, Sook Mei Khor

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