Evaluation of the potential of excretions-secretions (E-S) of Litomosoides carinii to substitute for human filarial E-S.

Parasitology Research
W HarnettR M Parkhouse

Abstract

The antigenic cross-reactivity of the excretions-secretions (E-S) of Litomosoides carinii was investigated. Immunoprecipitation using pooled sera from a number of human filarial infections in combination with sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis revealed variations in the cross-reactivity of individual molecules. Some were specific to L. carinii, the major examples in this category being two E-S components of 140 and 160 kDa released by day 40- to 42-day-old female worms. Another, a high-molecular-weight product of 26- to 28-day E-S, was broadly cross-reactive. A third group appeared to exhibit reactivity to antibody to some but not all human filarial parasites. The most striking examples of this were two distinct 14-kDa products that bound solely to antibodies in an onchocerciasis serum pool. These results are discussed in relation to the use of cross-reacting molecules in investigating the immunisation potential, defining the function, and evaluating the diagnostic utility of human filarial E-S.

References

Apr 1, 1986·Molecular and Biochemical Parasitology·I PetralandaW F Piessens
Dec 1, 1987·Molecular and Biochemical Parasitology·S RathaurR M Maizels
Nov 1, 1980·The American Journal of Tropical Medicine and Hygiene·E L SchillerH F Marroquín
Nov 1, 1981·The American Journal of Tropical Medicine and Hygiene·A OuaissiA Capron
Jan 1, 1981·Parasite Immunology·R M ParkhouseB M Ogilvie
Dec 1, 1948·British Journal of Pharmacology and Chemotherapy·F HAWKING, P SEWELL

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