PMID: 15348489Sep 7, 2004Paper

Evaluation of the potential of starch-based biodegradable polymers in the activation of human inflammatory cells

Journal of Materials Science. Materials in Medicine
Alexandra P MarquesJohn A Hunt

Abstract

The inflammatory response resulting from the implantation of a medical device may compromise its performance and efficiency leading, in certain cases, to the failure of the implant. Thus, the assessment of the behavior of inflammatory cells in vitro, constitutes a key feature in the evaluation of the adverse potential, or not, of new promising biomaterials. The objectives of this study were to determine whether starch-based polymers and composites activated human neutrophils. Blends of starch with ethylene-vinyl alcohol, with cellulose acetate and polycaprolactone, as well as composites based on all these materials filled with hydroxyapatite have been studied. A lysozyme assay was adapted to examine enzyme secretion from human neutrophils incubated with different starch-based materials. Changes in the free radical and degranulation activity of the neutrophil were also determined by measuring the luminescent response of Pholasin, a photoprotein that emits light after excitation by reactive oxygen species. The amount of lysozyme secreted by neutrophils incubated with the polymers did not exhibit significant differences between the tested materials. Results were in all cases similar to those obtained for the control (polypropylene...Continue Reading

Citations

Jan 9, 2008·Journal of Tissue Engineering and Regenerative Medicine·I B LeonorT Nakamura
Jan 3, 2006·Journal of Materials Science. Materials in Medicine·A P MarquesJ A Hunt
Feb 27, 2007·Journal of Materials Science. Materials in Medicine·C Cunha-ReisR L Reis

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