Evaluation of the prescribing patterns, adverse effects, and drug interactions of oral chemotherapy agents in an outpatient cancer center

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Jenna M SolomonEric H Bernicker

Abstract

Purpose Although oral chemotherapy offers advantages over intravenous chemotherapy, it creates a unique set of challenges. Potential barriers include treatment complexity, patient responsibility for medication adherence and monitoring, reduced healthcare contact, and increased financial burden. The purpose of this study is to estimate the prevalence of drug-related problems among a sample of patients treated with oral chemotherapy agents. Methods A single-center, retrospective chart review was conducted on patients prescribed oral chemotherapy at our institution between 1 January 2017 and 31 August 2017. The primary endpoint was the incidence of drug-related toxicities within 90 days of starting treatment. Secondary endpoints included incidence of drug-drug interactions, proportion of patients receiving medication education by a clinical pharmacist, and quantification of issues related to medication access. Results Charts of 100 patients were reviewed. Median time to oral chemotherapy receipt by the patient from the day the order was written was eight days. Prior to initiating therapy, 27% of patients received education by a clinical pharmacist. Toxicity checks were conducted by the provider at 30, 60, and 90 days for 80%, 65%,...Continue Reading

References

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May 2, 2012·Journal of Oncology Practice·Saul N WeingartMichael J Hassett
May 10, 2012·Journal of the National Comprehensive Cancer Network : JNCCN·Nikhil KhandelwalCheryl Pegus
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Citations

May 18, 2019·Archives of Pathology & Laboratory Medicine·Eric H Bernicker
Jun 13, 2020·Expert Opinion on Drug Safety·Vicente Escudero-VilaplanaMaria Sanjurjo-Sáez
Dec 6, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sung Hwan KimJu-Yeun Lee
Dec 11, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yun-Kyoung Song, Jung Mi Oh
Nov 7, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Jessica N Heck, Aaron A Null
Sep 13, 2020·Pharmaceutics·Dominique A GarrisonSharyn D Baker
Apr 30, 2021·Journal of Cancer Research and Clinical Oncology·H PrelyC Rioufol
Oct 1, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Aurelie FeralAurelie Lenglet

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