Evaluation of the profile of the immune cell infiltrate in lichen planus, discoid lupus erythematosus, and chronic dermatitis

Pathology
Mahmoud-Rezk A HusseinSaad M Atta

Abstract

The term 'interface dermatitis' refers to those dermatoses in which an inflammatory process involves the dermoepidermal junction, with injury and even necrosis of the basal cell keratinocytes. Interface dermatitis can be characterised further as being either vacuolar or lichenoid changes. Immune cell infiltrate is a constant feature in interface dermatitis. In this study, we hypothesised that 'the profile of the immune cell infiltrate varies between lichenoid and vacuolar interface dermatitis'. This investigation tries to test this hypothesis and to characterise immune cells in interface dermatitis. Thirty-one interface dermatitis lesions (interface dermatitis group: 19 cases of lichen planus, LP; and 12 cases of discoid lupus erythematosus, DLE) and 20 specimens of normal skin (control group) were examined using immunoperoxidase staining methods. Antibodies targeting histiocytes/dendritic cells (CD68+), T cells (CD3+), B cells (CD20+), T cells with either cytotoxic potential (TIA-1+) or cytotoxic activity (Granzyme-B+) were used to decorate the immune cells. In addition, 16 cases of chronic dermatitis [lichen simplex chronicus (LSC), non-interface dermatitis group] were included to substantiate findings in the interface dermat...Continue Reading

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Citations

Jun 27, 2015·Cutaneous and Ocular Toxicology·Mahmoud Rezk Abdelwahed Hussein
Aug 21, 2013·Journal of the American Academy of Dermatology·Xinhua LiKaiming Zhang
Mar 16, 2012·International Journal of Dermatology·Denise LageMaria Letícia Cintra
Oct 1, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·E MoscarellaM Ardigò
Mar 30, 2010·The British Journal of Dermatology·M GhoreishiJ P Dutz
Nov 17, 2015·Arthritis Research & Therapy·Benjamin F ChongChandra Mohan
Apr 20, 2014·TheScientificWorldJournal·Ryan B ThorpeBenjamin F Chong
Aug 11, 2015·Arthritis Research & Therapy·Jordan C Achtman, Victoria P Werth
Oct 22, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·B WeberD Simon
Apr 30, 2017·Experimental Dermatology·Daejin MinSeung-Schik Yoo
Sep 23, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Wendy Anne BoivinDavid James Granville
Aug 9, 2020·Frontiers in Immunology·Jessica L ChandrasekharLoren D Erickson
Aug 29, 2019·Expert Opinion on Therapeutic Targets·Christopher T TurnerDavid J Granville
Mar 6, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gudrun F Debes, Shannon E McGettigan
Jun 26, 2021·The Journal of Investigative Dermatology·Shannon N EstadtJ Michelle Kahlenberg

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