PMID: 11902121Mar 21, 2002Paper

Evaluation of the protective effect of oestradiol against toxicity induced by 6-hydroxydopamine and 1-methyl-4-phenylpyridinium ion (Mpp+) towards dopaminergic mesencephalic neurones in primary culture

Journal of Neurochemistry
S CallierDidier Pelaprat

Abstract

Recent findings suggest that gonadal steroid hormones are neuroprotective and may provide clinical benefits in delaying the development of Parkinson's disease. In this report we investigated the ability of oestradiol to protect mesencephalic dopaminergic neurones cultured in serum-free or serum-supplemented medium from toxicity induced by 6-hydroxydopamine or 1-methyl-4-phenylpyridinium ion (MPP+). The efficiency of both toxins and oestradiol was evaluated by tyrosine hydroxylase (TH) immunocytochemistry, [3H]dopamine ([3H]DA) uptake, length of dopaminergic processes and lactate dehydrogenase (LDH) release measurement. In cultures grown in serum-supplemented medium, a 2-h pre-treatment with high concentrations (10-100 microM) of 17beta-oestradiol or 17alpha-oestradiol, the stereoisomer with weak oestrogenic activity, protected both dopaminergic and non-dopaminergic neurones from toxicity induced by 6-hydroxydopamine (6-OHDA; 40 or 100 microM) and by the high MPP+ concentrations (50 microM) necessary to obtain significant neuronal death under those culture conditions. At these concentrations, MPP+ was no longer selective for dopaminergic neurones but affected all cells present in the culture. In contrast, the hormonal treatments...Continue Reading

Citations

Jan 11, 2011·Biologie aujourd'hui·Emmanuelle ApartisWilliam Rostène
Oct 29, 2004·Developmental Neuroscience·Brian K BarlowMona Thiruchelvam
May 5, 2009·Frontiers in Neuroendocrinology·Mélanie BourqueThérèse Di Paolo
Jul 19, 2005·Annals of the New York Academy of Sciences·James A DykensNeil Howell
Apr 5, 2003·Journal of Neurochemistry·Tiesong ShangCecilia J Hillard
Mar 13, 2014·Frontiers in Neuroendocrinology·Glenda E GilliesZahi Qamhawi
Jun 8, 2012·Journal of Neuroendocrinology·F L CamposG Baltazar
Sep 3, 2014·Parkinsonism & Related Disorders·N M GattoB Ritz
Jul 15, 2015·Biochimica Et Biophysica Acta·Agustina BessaGraça Baltazar
Jun 29, 2010·Experimental Neurology·Ana I Rodriguez-PerezJose L Labandeira-Garcia
Jul 30, 2014·Frontiers in Neuroanatomy·Jose L Labandeira-GarcíaAna I Rodríguez-Perez
Jan 30, 2003·Journal of Neurobiology·Tatiana Ivanova, Cordian Beyer
Dec 15, 2019·International Journal of Molecular Sciences·Yuan-Hao ChenBarry J Hoffer
Mar 7, 2020·Frontiers in Neurology·Sara OlivolaLorenza Driul
Aug 1, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jason K RussellPaul A Newhouse
Dec 31, 2003·Brain Research·Elzbieta Lorenc-KociWładysława Anna Daniel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.