Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats

Oxidative Medicine and Cellular Longevity
Rafa S Almeer, Ahmed E Abdel Moneim

Abstract

In the present investigation, the effect of olive leaf extract (OLE) on testicular damage induced in rats by an intraperitoneal injection of cisplatin (cis-diamminedichloroplatinum (CDDP)) at a dose of 5 mg/kg was tested. Rats were randomly divided into 4 groups: control, CDDP, OLE, and OLE + CDDP. After 5 days of CDDP treatment, body and testicular weights, histopathological alteration, and serum male sex hormone levels were determined. In addition to the biochemical and immunohistochemical changes in the testes, CDDP caused the disorganization of germinal epithelium and apoptosis by inducing Bax and inhibiting Bcl-2 protein expression. Testicular weights, catalase, serum testosterone, testicular enzymatic (including glutathione peroxidase, glutathione reductase, and superoxide dismutase) along with nonenzymatic (glutathione) antioxidants, and levels of luteinizing and follicle-stimulating hormones were significantly reduced in addition to a significant increase in testicular malondialdehyde and nitrite/nitrate levels when compared with the control group. OLE treatment markedly attenuated both biochemical and histopathological changes. The reproductive beneficial effects of OLE were mediated, at least partly, by inducing the n...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Mar 12, 2002·Methods in Enzymology·Ralf Dringen, Jan Mirko Gutterer
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Jul 18, 2006·Journal of Pineal Research·Ahmet AteşşahinOzgür Bulmuş
Nov 7, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Yolanda I Chirino, José Pedraza-Chaverri
Jul 8, 2010·The Journal of Pharmacology and Experimental Therapeutics·Lauren M AleksunesCurtis D Klaassen
Jun 8, 2012·Journal of Biomedicine & Biotechnology·Amr AminSayel Daoud
Jan 15, 2013·Nutrition & Metabolism·Ulkan KilicKazim Sahin
Jul 6, 2014·Indian Journal of Pharmacology·Ahmed Esmat Abdel Moneim
Aug 19, 2014·Journal of Biochemical and Molecular Toxicology·Iman O SherifOsama M Sarhan
Aug 28, 2014·BioMed Research International·Ahmed E Abdel MoneimAhmed M Aref
Jan 1, 2013·Antioxidants·Maurizio ServiliAgnese Taticchi
Mar 2, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K Pratap ReddyP Sreenivasula Reddy
May 4, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saleh Al-QuraishyAhmed Esmat Abdel Moneim
May 10, 2017·Pharmaceutical Biology·Amr A FouadWalid N Al-Melhim
Jul 27, 2017·Toxicological Research·Ali Reza FallahzadehReza Mahmoudi

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Citations

May 2, 2019·Experimental Biology and Medicine·Iman O Sherif, Osama M Sarhan
Nov 20, 2018·Anti-cancer Agents in Medicinal Chemistry·Rafa S AlmeerAhmed E Abdel Moneim
Jan 5, 2020·Environmental Science and Pollution Research International·Nastaran AzarbarzEsrafil Mansouri
Mar 3, 2019·International Journal of Molecular Sciences·Mohamed A DkhilSaleh Al-Quraishy
Jan 30, 2020·Environmental Science and Pollution Research International·Saleh Al-QuraishyAhmed E Abdel Moneim
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·María Del Carmen Villegas-AguilarAntonio Segura-Carretero
Aug 16, 2019·International Journal of Environmental Research and Public Health·Al Omar S YousefRami B Kassab
Jul 4, 2021·Environmental Science and Pollution Research International·Harith Abdulrhman AhmedThulfiqar Fawwaz Mutar
Sep 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hussein A Abd ElmaksoudAsmaa Ibrahimi
Nov 26, 2021·Journal of Biochemical and Molecular Toxicology·Atena RahimiZahra Memariani

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Methods Mentioned

BETA
ELISA
MDA
PCR

Software Mentioned

SPSS

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