Evaluation of the pulmonary toxicity of plasticized polyvinyl chloride thermal decomposition products in guinea pigs by repeated CO2 challenges

Toxicology and Applied Pharmacology
K L WongY Alarie

Abstract

Male guinea pigs were exposed to thermal decomposition products of plasticized polyvinyl chloride (PVC-A) at different concentrations up to levels inducing acute lethality. Several groups exposed at sublethal levels were then evaluated for pulmonary performance for a period of 57 days following exposure. Pulmonary performance was evaluated by challenging each animal with a mixture containing 10% CO2, 20% O2, and 70% N2. In control animals, this mixture induced an increase in both tidal volume and respiratory frequency. This hyperventilatory response was greatly depressed during the first 3 days following exposure and gradually returned to normal during the following weeks with the exception of the highest exposure group which still showed a diminished response 57 days after exposure. The pulmonary toxicity induced by thermal decomposition products of PVC-A is probably related to the very large amount of HCl released during thermal decomposition. The CO2 response test, a nonintrusive and noninvasive method to evaluate pulmonary performance in guinea pigs, is easily performed and appears to be a very promising type of pulmonary function test for toxicological evaluations.

References

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Citations

Jan 29, 2002·International Immunopharmacology·V CastranovaR D Dey
Jun 30, 1984·Toxicology and Applied Pharmacology·M A EllakkaniM H Karol
Jan 1, 1985·Journal of Toxicology and Environmental Health·K L WongY Alarie
Jun 30, 1985·Toxicology and Applied Pharmacology·M SchaperY Alarie

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