Evaluation of the Quality of Semen and Sexual Function in Men with Inflammatory Bowel Disease

Inflammatory Bowel Diseases
Paz ValerF Bermejo

Abstract

Data on fertility rates and medication safety in men with inflammatory bowel disease (IBD) are limited. The aim of this study was to evaluate whether there is a seminal alteration in patients with IBD and, if so, to evaluate the mechanisms that may play a role according to what has been described in the literature. Its secondary aim was to evaluate the impact on male sexual function of IBD. Multicenter, cross-sectional, case series study comparing men with IBD and control subjects. Semen analysis was performed according to the recommendations of World Health Organization. The impact on male sexual function was evaluated with the International Index of Erectile Function questionnaire. On multivariate analysis, patients with Crohn's disease had lower sperm concentrations compared with those with ulcerative colitis (median [interquartile range], 34.5 [19.2-48] versus 70 [34.5-127.5], P = 0.02) and lower seminal zinc levels (mean ± SD, 1475 ± 235 μmol/L versus 2221 ± 1123 μmol/L, P = 0.04). Patients with Crohn's disease on anti-tumor necrosis factor treatment had better progressive motility (mean ± SD, 56.7 ± 17.7 versus 35.1 ± 22.1, P = 0.01) and sperm morphology (14.4 ± 7.1 versus 7.6 ± 4.9, P = 0.04) than those who were not on a...Continue Reading

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Citations

Jun 20, 2018·Journal of Crohn's & Colitis·Anne GrosenJens Kelsen
Apr 27, 2019·Expert Opinion on Drug Safety·Aviv PudipeddiRupert Wl Leong
Feb 6, 2020·The American Journal of Gastroenterology·Muhammad B Hammami, Uma Mahadevan
Jul 16, 2020·Journal of Clinical Nursing·Sara MaPaul Galdas
Jun 4, 2021·International Journal of General Medicine·Edith Perez de ArceLigia Yukie Sassaki

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