Evaluation of the relationship between endometriosis and omega-3 and omega-6 polyunsaturated fatty acids.

Iranian Biomedical Journal
Korosh KhanakiAli Rahimipour

Abstract

Endometriosis is a common chronic inflammation causing major problems including infertility. The role of omega-3 and omega-6 fatty acids as their potential anti-inflammatory effects in endometriosis needs to be further explored. The objective of this study was to compare serum phospholipid fatty acid profile in endometriosis patients with controls, and to explore the correlation of this profile with the severity of the disease. Sixty-four endometriosis patients and 74 control women, in reproductive age, participated in this study. Among the endometriosis patients, 19 cases were in stage I, 27 cases in stage II, 8 cases in stage III, and 10 cases in stage IV. Each patient underwent laparoscopy. Before surgery, 5 ml of blood was obtained. After extraction of the total lipids, serum total phospholipid fraction was isolated by thin layer chromatography. Fatty acid composition of the phospholipid fraction was determined by gas chromatography and the resulted profile was compared in endometriosis patients and controls. The profile was also compared in the endometriosis group based on the severity of disease. Stearic acid was significantly lower in the endometriosis group as compared to controls (P= 0.030). No other fatty acid composi...Continue Reading

Citations

Aug 5, 2015·BioMed Research International·Amelie FassbenderLinda Giudice
Dec 23, 2020·International Journal of Molecular Sciences·Małgorzata SzczukoMaciej Ziętek

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