PMID: 6165576Jan 1, 1981Paper

Evaluation of the release of mutagens from diesel particles in the presence of physiological fluids

Environmental Mutagenesis
L C KingJ L Huisingh

Abstract

The Ames Salmonella typhimurium plate incorporation assay was used to evaluate the mutagenicity of organics extracted from diesel exhaust particles. Organic solvents were more efficient than physiological fluids in removing mutagens from diesel particles, with dichloromethane extracts having the greatest mutagenic activity of the solvents examined. Serum and lung cytosol were more effective than acellular lung lavage fluid in releasing mutagenic activity from diesel particles. The mutagenic activity of diesel particle organics preextracted with dichloromethane is greatly reduced upon the addition of serum and lung cytosol to organics. Subsequently, incubation of protease with serum and lung cytosol-bound diesel organics increases the mutagenic activity. Fluorescence intensity was quantitated and found to correlate with mutagenic activity in the organic and serum extracts, but not the lung cytosol extracts. These studies suggest that substantial mutagenic activity is released from diesel particles upon incubation with serum and lung cytosol.

References

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Citations

May 1, 1984·Bulletin of Environmental Contamination and Toxicology·C WeiM F Richter
Sep 1, 1995·Environmental Science and Pollution Research International·P ThomasB Przybilla
Feb 1, 1983·Mutation Research·E C McCoyR Mermelstein
Jan 1, 1987·Journal of Toxicology and Environmental Health·W E WallaceT M Ong
Jun 4, 2004·Environmental Health Perspectives·David M DeMariniPramila Singh
Dec 1, 1986·Environmental Health Perspectives·G MatanoskiL Wallace
Sep 1, 1983·American Journal of Public Health·E T Wei, H P Shu
Apr 1, 1992·Environmental Research·M B SchenkerT J Smith
Oct 20, 2006·Critical Reviews in Toxicology·Thomas W HesterbergGeorgia A Hart
Jan 1, 1992·International Archives of Occupational and Environmental Health·P T Scheepers, R P Bos
Jan 1, 1984·Environmental Mutagenesis·R W ShimizuA L Brooks
Jan 1, 1986·Critical Reviews in Toxicology·H Tokiwa, Y Ohnishi
Jun 24, 1999·Inhalation Toxicology·P A Valberg, A Y Watson

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