Evaluation of the response to vaccination with hepatitis B vaccine in pediatric patients diagnosed with celiac disease

SAGE Open Medicine
Dorota Walkiewicz-JedrzejczakJens Eickoff

Abstract

A gap exists in the literature on celiac disease populations and the response to hepatitis B vaccination. To identify pediatric patients with celiac disease who received the primary hepatitis B vaccination and investigate their response to vaccine. Patients underwent blood draw for hepatitis B surface antibody titers. Patients with undetectable or non-protective HBsAb titers were contacted. Study outcome measures and patient characteristics variables were summarized by means, standard deviations, medians, and ranges. A two-sample t-test was used to compare normally distributed continuous variables between responders and non-responders. In all, 58% of patients did not meet the threshold for "protective" antibody titers. The mean time between completion of hepatitis B vaccination and diagnosis of celiac disease was 8.1 years for responders versus 10.5 years for non-responders. In a multivariate analysis, time between completion of vaccine and diagnosis of celiac disease was statistically significant predictor of response with an adjusted odds ratio of 0.69 (95% confidence interval: 0.50-0.95; p = 0.021). Our celiac disease population shows a high hepatitis B vaccine failure. The time between completion of vaccine series and diagn...Continue Reading

References

May 1, 1990·Archives of Disease in Childhood·S LeonardiS Musumeci
Apr 7, 2007·Journal of Pediatric Gastroenterology and Nutrition·Seung-Dae ParkJeremiah Levine
Dec 25, 2007·Digestive Diseases and Sciences·Emel AhishaliZeynel Mungan
Jul 9, 2009·European Journal of Gastroenterology & Hepatology·Deniz ErtemEmel Eksioglu-Demiralp
Feb 23, 2013·World Journal of Gastroenterology : WJG·Giovanna VitalitiSalvatore Leonardi
Apr 4, 2013·Hepatitis Monthly·Giovanna VitalitiSalvatore Leonardi

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Citations

Mar 15, 2019·Clinical Microbiology Reviews·Petra Zimmermann, Nigel Curtis
Jun 11, 2020·Vaccines·Stefano PassanisiClaudio Romano
Mar 31, 2021·Expert Review of Vaccines·Guan-Huei Lee, Seng-Gee Lim

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Methods Mentioned

BETA
biopsy
blood drawn
blood draws
blood drawing
blood draw

Software Mentioned

SAS

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