Evaluation of the Retinal Vasculature in Hypertension and Chronic Kidney Disease in an Elderly Population of Irish Nuns

PloS One
Amy McGowanGareth J McKay

Abstract

Chronic kidney disease (CKD) and hypertension are global public health problems associated with considerable morbidity, premature mortality and attendant healthcare costs. Previous studies have highlighted that non-invasive examination of the retinal microcirculation can detect microvascular pathology that is associated with systemic disorders of the circulatory system such as hypertension. We examined the associations between retinal vessel caliber (RVC) and fractal dimension (DF), with both hypertension and CKD in elderly Irish nuns. Data from 1233 participants in the cross-sectional observational Irish Nun Eye Study (INES) were assessed from digital photographs with a standardized protocol using computer-assisted software. Multivariate regression analyses were used to assess associations with hypertension and CKD, with adjustment for age, body mass index (BMI), refraction, fellow eye RVC, smoking, alcohol consumption, ischemic heart disease (IHD), cerebrovascular accident (CVA), diabetes and medication use. In total, 1122 (91%) participants (mean age: 76.3 [range: 56-100] years) had gradable retinal images of sufficient quality for blood vessel assessment. Hypertension was significantly associated with a narrower central ret...Continue Reading

References

May 22, 1995·Archives of Internal Medicine·D D MakiB L Kasiske
Jan 27, 1993·JAMA : the Journal of the American Medical Association·T V PernegerM Szklo
Jun 19, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B L KasiskeT A Louis
Oct 30, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M M SchwartzD Batlle
Aug 8, 2001·Circulation·B I LevyH A Struijker-Boudier
May 16, 2002·Clinical & Experimental Ophthalmology·Lauren M SherryPaul Mitchell
Oct 17, 2003·Current Eye Research·Michael D KnudtsonBarbara E K Klein
Oct 28, 2003·Investigative Ophthalmology & Visual Science·Tien Yin WongLarry D Hubbard
Feb 19, 2004·Annals of Internal Medicine·Tien Yin WongUNKNOWN Atherosclerosis Risk in Communities Study
Jun 4, 2004·BMJ : British Medical Journal·Tien Yin WongLarry D Hubbard
Sep 2, 2004·Journal of the American Society of Nephrology : JASN·Tien Yin WongBruce B Duncan
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Matthew S EdwardsKimberley J Hansen
Dec 29, 2005·Hypertension·M Kamran IkramPaulus T V M de Jong
Jun 28, 2006·Hypertension·Gerald LiewJie Jin Wang
Jan 2, 2007·Investigative Ophthalmology & Visual Science·Gerald LiewJie Jin Wang
Mar 21, 2007·Hypertension·Paul MitchellTien Y Wong
Apr 19, 2007·Kidney International·P E StevensC K T Farmer
May 13, 2008·American Journal of Epidemiology·Jie Jin WangPaul Mitchell
Dec 19, 2008·American Journal of Epidemiology·Charumathi SabanayagamTien Yin Wong
Jan 28, 2009·Survey of Ophthalmology·Cong SunTien Y Wong
Mar 6, 2009·Journal of Hypertension·George L BakrisUNKNOWN World Kidney Day Steering Committee
Jul 22, 2009·Journal of Hypertension·Charumathi SabanayagamTien Y Wong
Aug 15, 2009·Journal of Hypertension·Ryo KawasakiTien Y Wong
Aug 29, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·V Swetha E JeganathanTien Yin Wong
Dec 10, 2009·Kidney & Blood Pressure Research·Marcus BaumannInes Lanzl
Feb 4, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chelvin C A SngTien Y Wong
Feb 19, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Yusuke TanabeHidetoshi Yamashita
Mar 27, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew S Levey, Lesley A Stevens
Apr 23, 2010·Journal of the American Society of Hypertension : JASH·George L BakrisUNKNOWN World Kidney Day Steering Committee
Dec 9, 2010·European Heart Journal·Gerald LiewJie Jin Wang
Mar 29, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Charumathi SabanayagamRonald Klein
Mar 30, 2011·Ophthalmology·Ling-Jun LiSeang-Mei Saw
May 10, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joanne Wen Yee YauTien Yin Wong
Sep 13, 2011·American Journal of Ophthalmology·Muhammad Bayu SasongkoJie Jin Wang
Nov 18, 2011·Diabetes Research and Clinical Practice·Joanne Wen Yee YauTien Y Wong
Dec 30, 2011·Investigative Ophthalmology & Visual Science·Emil D KurniawanTien Yin Wong
Mar 23, 2012·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Jie DingTien Yin Wong

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Citations

May 17, 2017·Journal of Hypertension·Mirna KirinVeronique Vitart
Sep 24, 2019·Acta Ophthalmologica·Jeremy NadalVincent Daien
Aug 7, 2018·The Journal of Nutrition, Health & Aging·C E NevilleG J McKay
Jul 22, 2021·European Journal of Ophthalmology·Meng LiJin Yuan

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Software Mentioned

Fractal
IRIS
Interactive Vessel ANalysis software IVAN
Interactive Vessel Analysis IVAN
FA
SPSS Statistics
IVAN
SIVA

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