Evaluation of the rewarding properties of nicotine and caffeine by implementation of a five-choice conditioned place preference task in zebrafish

Progress in Neuro-psychopharmacology & Biological Psychiatry
M P FaillaceR O Bernabeu

Abstract

The rewarding properties of drugs in zebrafish can be studied using the conditioned place preference (CPP) paradigm. Most devices that have been used for CPP consist of two-half tanks with or without a central chamber. Here we evaluated the rewarding effects of nicotine and caffeine using a tank with five arms distributed radially from a central chamber that we have denoted Fish Tank Radial Maze (FTRM). Zebrafish were trained to associate nicotine or caffeine with a coloured arm. In testing sessions to assess CPP induction, between two and five different arms were available to explore. We found that when offering the two arms, one of them associated to the drug mediating conditioning for 14 days, zebrafish showed nicotine-induced CPP but not caffeine-induced CPP. When zebrafish had the option to explore drug-paired arms together with new coloured arms as putative distractors, the nicotine-CPP strength was maintained for at least three days. The presence of novel environments induced caffeine-CPP, which was still positive after three days of testing sessions. Complementary behavioural data supported these findings. Nicotine-CPP was prevented by the histone deacetylase inhibitor phenylbutyrate administered during conditioning; ho...Continue Reading

Citations

Mar 22, 2019·Addiction Biology·Andreas HeinzGaetano Di Chiara
Jul 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Franco ViscarraPatricio Iturriaga-Vásquez
Nov 27, 2020·Journal of Toxicologic Pathology·Izuru Miyawaki
Apr 14, 2021·The Journal of Clinical Investigation·Gabriel D BosseRandall T Peterson
Jun 5, 2021·Neuroscience and Biobehavioral Reviews·Radharani BenvenuttiAngelo Piato

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