Evaluation of the role of coronary angioplasty in patients with unstable angina pectoris

American Heart Journal
D O WilliamsA S Most

Abstract

Seventeen patients presenting with unstable angina pectoris underwent percutaneous transluminal coronary angioplasty (PTCA). Despite vigorous medical therapy, all patients were disabled with 10 experiencing refractory in-hospital angina. PTCA was judged successful in 13 patients and resulted in decreased coronary diameter narrowing from 80 +/- 16% to 34 +/- 13% and reduced transstenotic pressure gradient from 69 +/- 13 to 23 +/- 12 mm Hg. Regional coronary blood flow (CBF) and myocardial metabolism were assessed at rest and during pacing tachycardia in six patients with left anterior descending coronary stenosis. Prior to PTCA, neither regional CBF increased nor coronary vascular resistance declined during rapid pacing; myocardial lactate extraction fell, indicating a shift from aerobic to anerobic metabolism. Following PTCA, however, rapid pacing resulted in increased regional CBF, decreased coronary vascular resistance, and preservation of aerobic metabolism. Following PTCA, successfully dilated patients demonstrated marked relief of angina symptoms, increase in functional capacity, and objective exercise ECG and thallium scintigraphic evidence of relief of previously ischemic myocardium. This investigation demonstrates that ...Continue Reading

References

Aug 1, 1979·American Heart Journal·G D Plotnick
Jul 12, 1979·The New England Journal of Medicine·A R GrüntzigW E Siegenthaler
Dec 13, 1979·The New England Journal of Medicine·L S Cohen
Jun 1, 1978·The American Journal of Cardiology·B PughJ T Willerson
Dec 25, 1975·The New England Journal of Medicine·R SeldenR P Anderson

❮ Previous
Next ❯

Citations

May 1, 1988·Cardiovascular Drugs and Therapy·P J de FeyterP G Hugenholtz
Jan 1, 1986·Cardiovascular and Interventional Radiology·G S RoubinW J Casarella
Jul 1, 1981·American Heart Journal·E A AmsterdamD T Mason
Dec 1, 1988·Journal of the American College of Cardiology·H SuryapranataP W Serruys
Feb 1, 1989·Journal of the American College of Cardiology·J M NicklasB Pitt
Jul 1, 1994·Journal of the American College of Cardiology·A E AbdelmeguidP L Whitlow
Jul 1, 1991·Journal of the American College of Cardiology·C CostantiniR V Haendchen
May 1, 1983·Journal of the American College of Cardiology·D O WilliamsA S Most
Mar 1, 1984·Journal of the American College of Cardiology·D R HolmesH V Schaff
Jun 1, 1984·Journal of the American College of Cardiology·W W O'NeillR A Vogel
Aug 1, 1985·Journal of the American College of Cardiology·D R BresnahanH C Smith
Aug 8, 1985·The New England Journal of Medicine·P J de FeyterP G Hugenholtz
Jun 11, 2002·Journal of Interventional Cardiology·S R GangasaniC L Grines
May 1, 1987·British Heart Journal·G SteffeninoW Rutishauser
Oct 1, 1982·Chest·H S Hecht, S H Rahimtoola
Sep 3, 1991·The American Journal of Cardiology·P J de FeyterP G Hugenholtz
Nov 1, 1987·Progress in Cardiovascular Diseases·S K ChokshiP Abi-Mansour
Mar 1, 1984·International Journal of Cardiology·A T WeissB S Lewis
Jan 1, 1987·International Journal of Cardiology·A D TimmisE Sowton
Jun 15, 1984·The American Journal of Cardiology·D O WilliamsT To
Dec 1, 1986·Circulation·P J de FeyterP G Hugenholtz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.