Evaluation of the role of the critical care pharmacist in identifying and avoiding or minimizing significant drug-drug interactions in medical intensive care patients

Journal of Critical Care
Anastasia Rivkin, Hongjun Yin

Abstract

The aim of the study was to evaluate the impact of prospective review of significant drug-drug interactions (DDIs) occurring in medical intensive care unit (MICU) patients by the critical care pharmacist participating in patient care rounds on improvement of safer and more efficacious medication use. A prospective consecutive 10-week study was conducted in the MICU, St Luke's/Roosevelt Hospital Center (St Luke's site), New York, NY. This study compared baseline period when clinical pharmacist services were not provided with the period when each patient's profile was reviewed daily during MICU rounds and interactions were minimized. The study examined whether the presence of critical care pharmacist would decrease the number of significant DDIs in the MICU. Impact of decreasing presence of severe DDIs on length of stay (LOS) and discharge status was also evaluated. Having a pharmacist on rounds resulted in statistically significant decrease in number of clinically important interactions requiring therapy modification, rated D-X (Poisson regression B = -1.036; 95% confidence interval, -1.318 to -0.753; P < .01). The coefficient (-1.036) indicates the incidence rate ratio of 0.35, meaning that the presence of clinical pharmacist i...Continue Reading

References

Jul 5, 1995·JAMA : the Journal of the American Medical Association·L L LeapeG Laffel
Jul 28, 1999·JAMA : the Journal of the American Medical Association·L L LeapeD W Bates
Nov 26, 2003·Archives of Internal Medicine·Saul N WeingartRussell S Phillips
Sep 16, 2005·Chest·Basim A Dubaybo, John D Dingell
Feb 11, 2009·Archives of Internal Medicine·Thomas IsaacSaul N Weingart
Nov 20, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jared J Cash

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Citations

May 2, 2012·Annals of Internal Medicine·Elizabeth H BradleyHarlan M Krumholz
May 3, 2013·Journal of the American Pharmacists Association : JAPhA·Aleda M H ChenMatthew M Murawski
Nov 6, 2013·Chest·Candice R PreslaskiJason Poston
Feb 1, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A CorsonelloF Lattanzio
Jun 15, 2013·The International Journal of Pharmacy Practice·Richard S BourneBen J Dorward
Mar 17, 2016·Critical Care Medicine·Frederick A ZeilerFrancis Bernard
Nov 1, 2016·European Journal of Clinical Pharmacology·Giok Qin NgHui Ting Chng
Dec 25, 2015·PloS One·Jessalyn K HolodinskyHenry T Stelfox
Feb 20, 2018·The Annals of Pharmacotherapy·Joanna L StollingsCarla M Sevin
Oct 20, 2018·Biomédica : revista del Instituto Nacional de Salud·Marcela HernándezCarlos Bustamante
May 12, 2018·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Daniel L HertzSiu Fun Wong
Dec 17, 2014·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Elizabeth MichaletsWilliam R Shillinglaw
Apr 9, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kayla E McGahey, Glen J Weiss
May 8, 2019·International Journal of Environmental Research and Public Health·Ying-Chyi ChouKuan-Ming Lai
Sep 5, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Lorry R FrankelUNKNOWN Voting Panel
Jul 22, 2020·Journal of Pharmacy Practice·Farrah C TavakoliStacy E Dalpoas
Dec 16, 2018·International Journal of Clinical Pharmacy·Renato Rocha MartinsFlavio Marques Lopes
Oct 9, 2019·International Journal of Clinical Pharmacy·C ChapuisJ F Payen
Aug 23, 2020·Critical Care Medicine·Ishaq LatTricia A Meyer
Aug 12, 2016·Turkish Journal of Medical Sciences·Medine Gülçebi İdriz OğluMehmet Zafer Gören
Jul 12, 2019·Journal of Pharmacy Practice·Sandra L Kane-Gill, Amy L Dzierba
May 18, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Mary Grace FitzmauriceSandra L Kane-Gill
Oct 28, 2020·Journal of Advanced Nursing·Juan Escrivá GraciaJulio Fernández Garrido
Jul 20, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Curtis D CollinsJason P Hecht

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