Evaluation of the role of the pharmacological inhibition of Staphylococcus aureus multidrug resistance pumps and the variable levels of the uptake of the sensitizer in the strain-dependent response of Staphylococcus aureus to PPArg(2)-based photodynamic inactivation

Photochemistry and Photobiology
Mariusz GrinholcKrzysztof P Bielawski

Abstract

The emergence of antibiotic resistance among pathogenic bacteria has caused an urgent need for the development of alternative therapeutics. One possibility is a combination of nontoxic photosensitizers (PS) and visible light, recognized as photodynamic therapy. Although it is known that Staphylococcus aureus is susceptible to photodynamic inactivation (PDI), the factors that determine the emerging variation among strains in the response to the treatment remain unclear. Some data indicate that cationic photosensitizing dyes such as phenothiaziniums which vary a lot in the chemical structure might target multidrug resistance pumps. In this study, we analyzed whether the uptake and activity of the multidrug resistance pumps might influence the previously observed variations among the clinical strains to protoporphyrin-derived, amphipilic protoporphyrin diarginate-mediated photodynamic treatment (12 J cm(-2) ). Using a new set of four additionally selected methicillin-resistant and methicillin-susceptible clinical as well as ATCC S. aureus strains we confirmed that the bactericidal effect of the PDI is strain-dependent as it ranged from 0 to 5 log(10) -unit reduction in viable counts. However, neither the variable levels of the upt...Continue Reading

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Citations

Nov 12, 2013·Journal of Photochemistry and Photobiology. B, Biology·Mariusz GrinholcKrzysztof P Bielawski
Jan 12, 2012·Photochemistry and Photobiology·Christine M N YowZheng Huang
Jan 17, 2012·Photochemistry and Photobiology·Domingo Mariano Adolfo VeraGeorge P Tegos
Oct 26, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A Rapacka-ZdonczykM Grinholc
Mar 20, 2013·BioMed Research International·Aleksandra TaraszkiewiczJoanna Nakonieczna
Apr 10, 2013·The Open Microbiology Journal·Christina KourtesiGeorge P Tegos
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Feb 23, 2012·Journal of Industrial Microbiology & Biotechnology·Tim MaischWolfgang Bäumler
Jun 1, 2021·Frontiers in Medicine·Aleksandra Rapacka-ZdończykJoanna Nakonieczna

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Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.