Evaluation of the Sensitivity of Inhomogeneous Magnetization Transfer (ihMT) MRI for Multiple Sclerosis

AJNR. American Journal of Neuroradiology
E Van ObberghenG Duhamel

Abstract

Inhomogeneous magnetization transfer is a new endogenous MR imaging contrast mechanism that has demonstrated high specificity for myelin. Here, we tested the hypothesis that inhomogeneous magnetization transfer is sensitive to pathology in a population of patients with relapsing-remitting MS in a way that both differs from and complements conventional magnetization transfer. Twenty-five patients with relapsing-remitting MS and 20 healthy volunteers were enrolled in a prospective MR imaging research study, whose protocol included anatomic imaging, standard magnetization transfer, and inhomogeneous magnetization transfer imaging. Magnetization transfer and inhomogeneous magnetization transfer ratios measured in normal-appearing brain tissue and in MS lesions of patients were compared with values measured in control subjects. The potential association of inhomogeneous magnetization transfer ratio variations with the clinical scores (Expanded Disability Status Scale) of patients was further evaluated. The magnetization transfer ratio and inhomogeneous magnetization transfer ratio measured in the thalami and frontal, occipital, and temporal WM of patients with MS were lower compared with those of controls (P < .05). The mean inhomog...Continue Reading

References

Jun 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A MacKayD Graeb
Apr 26, 2001·NMR in Biomedicine·R M HenkelmanS J Graham
Oct 25, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J G Sled, G B Pike
Jul 12, 2002·Journal of Neurology·A Carlos SantosDouglas L Arnold
Dec 11, 2003·Multiple Sclerosis : Clinical and Laboratory Research·A TraboulseeD H Miller
Sep 7, 2004·Annals of Neurology·Klaus SchmiererDavid H Miller
Apr 12, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Massimo Filippi, Federica Agosta
Dec 14, 2011·Annals of Neurology·Natalia M MollElizabeth Fisher
Mar 8, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gopal VarmaDavid C Alsop
Jun 26, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Olivier M GirardGuillaume Duhamel
Mar 10, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Olivier M GirardGuillaume Duhamel
Apr 1, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Scott D SwansonAshok Srinivasan
Nov 20, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gopal VarmaDavid C Alsop
Dec 6, 2016·Journal of Magnetic Resonance·Alan P ManningCarl A Michal
Sep 25, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Samira MchindaOlivier M Girard

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Citations

Sep 21, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shaihan J MalikJoseph V Hajnal
Feb 15, 2020·Annals of Neurology·Russell OuelletteTobias Granberg
Jul 1, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gopal VarmaDavid C Alsop
Sep 17, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gian Franco PireddaTobias Kober
May 18, 2020·AJNR. American Journal of Neuroradiology·H RasoanandrianinaV Callot
Apr 6, 2019·Current Opinion in Neurology·Chenyu Tim WangYael Barnett
Aug 26, 2020·Wellcome Open Research·Tobias C WoodSteven C R Williams
Apr 30, 2019·Frontiers in Neurology·Mohamed Mounir El MendiliPierre-François Pradat
Aug 10, 2019·Brain Sciences·Zakir ShaikhMasanori Takeoka
Aug 22, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel J WestShaihan J Malik
Nov 16, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lucas SoustelleOlivier M Girard
Jan 18, 2022·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Andreea HertanuGuillaume Duhamel

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