Evaluation of the Serotonin Transporter Ligand 123I-ADAM for SPECT Studies on Humans

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Vibe G FrokjaerGitte M Knudsen

Abstract

Imaging serotonin transporters in the living human brain is important in several fields, such as normal psychophysiology, mood disorders, eating disorders, and neurodegenerative disorders. The aim of this study was to compare different kinetic and semiquantitative methods for assessing serotonin transporters using (123)I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) in humans: an arterial plasma input model, simplified and Logan reference tissue models, and standardized uptake value ratios. Nine subjects were scanned with dynamic (123)I-ADAM SPECT (mean age, 31 y; range, 24-43 y), and metabolite-corrected arterial input was measured. Tissue reference models (simplified reference tissue model, Logan reference tissue model, and ratio method) were validated against the outcome of a 1-tissue-compartment model, and performance with decreasing scan length was evaluated. The specificity of (123)I-ADAM binding was investigated in a blocking experiment. Binding estimates from the simplified reference tissue and Logan reference tissue models correlated tightly with full kinetic modeling when based on a 240- or 360-min dynamic acquisition (r = 0.99); however, there were slight underestimations (3%-5%), especia...Continue Reading

References

Jul 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H W Müller-GärtnerJ J Frost
Jul 1, 1992·Journal of Computer Assisted Tomography·R P WoodsJ C Mazziotta
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R E CarsonP Herscovitch
Dec 1, 1996·NeuroImage·A A Lammertsma, S P Hume
Nov 20, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yiyun HuangMarc Laruelle
Dec 31, 2003·Nuclear Medicine and Biology·Jean Logan
Jun 15, 2004·Human Brain Mapping·Katarina VarnäsHåkan Hall
Nov 6, 2004·Neuroscience and Biobehavioral Reviews·Swen HesseUlrich Müller
Jul 20, 2005·Biological Psychiatry·Nicole Praschak-RiederJeffrey H Meyer
Sep 1, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Kjell ErlandssonPeter J Ell
Feb 21, 2006·The International Journal of Neuropsychopharmacology·Julia SacherJohannes Tauscher
Mar 21, 2006·Nuclear Medicine and Biology·Jan Booij, Maartje M L de Win
Sep 2, 2006·The International Journal of Neuropsychopharmacology·Steven HaugbølGitte M Knudsen
Mar 14, 2007·Journal of Neurology·Sigrid Schuh-HoferGuy Arnold
May 24, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert B InnisRichard E Carson

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Citations

Mar 24, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Elsmarieke van de Giessen, Jan Booij
May 27, 2014·Nuclear Medicine and Biology·F GourandC Halldin
Feb 26, 2009·Psychiatry Research·Yuan-Hwa ChouShyh-Jen Wang
Jun 16, 2011·Medicinal Research Reviews·Louise M PatersonGitte M Knudsen
Mar 26, 2016·Cephalalgia : an International Journal of Headache·Marie DeenMessoud Ashina

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