Evaluation of the severity of chronic hepatitis C with 3-T1H-MR spectroscopy

AJR. American Journal of Roentgenology
Antonio OrlacchioGiovanni Simonetti

Abstract

The purpose of this study was to compare the spectral characteristics of lipids, choline-containing compounds, and glutamine-glutamate complex assessed with (1)H-MR spectroscopy with the histologic findings in patients with chronic hepatitis C. Nine healthy controls and 30 patients with biopsy-proven hepatitis C virus-related liver disease participated in this prospective study. Degree of fibrosis and histologic activity were scored according to the METAVIR classification. The percentage of involved hepatocytes was used to grade steatosis. Hepatic spectra were obtained with a 3-T spectroscopic system. Tenfold cross-validated stepwise discriminant analysis was performed to classify disease severity on the basis of the spectroscopic findings. There was a strong correlation between (1)H-MR spectroscopically measured lipid concentration and the degree of steatosis at histologic examination (r = 0.9236, p < 0.0001). This finding enabled clear separation of groups according to degree of histologically determined steatosis. Variation in lipid concentration was consistent with the degree of steatosis (r = 0.7265, p < 0.0001) and stage of fibrosis (r = 0.8156, p < 0.0001). In univariate analysis, concentrations of both choline-containin...Continue Reading

References

Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N BachF Schaffner
Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E E PowellL W Powell
Jun 1, 1989·Human Pathology·R G Lee
Jan 1, 1994·Magnetic Resonance Imaging·C ThomsenO Henriksen
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P SimmondsD S Chen
Nov 25, 1993·Biochimica Et Biophysica Acta·J D BellJ Urenjak
Jan 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MathurinT Poynard
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·G BarbaC Bréchot
Apr 1, 1997·Virchows Archiv : an International Journal of Pathology·E BierhoffJ Oldenburg
Jul 1, 1997·The Journal of General Virology·K MoriyaK Koike
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L SerfatyR Poupon
Aug 29, 1998·Journal of Hepatology·A J CzajaS B Moore
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L F HouriganE E Powell
Nov 30, 1999·JAMA : the Journal of the American Medical Association·H Cortez-PintoA M Diehl
Jul 11, 2000·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·T PoynardP Bedossa
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J F CadranelF Degos
Apr 3, 2001·Journal of Hepatology·A D CloustonE E Powell
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L E AdinolfiG Ruggiero
Jul 24, 2002·The American Journal of Gastroenterology·Lawrence SerfatyRaoul Poupon
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Adrian K P LimSimon D Taylor-Robinson
May 13, 2003·Scandinavian Journal of Gastroenterology·I SiddiqueF Hasan
Mar 20, 2004·Journal of Hepatology·Stephen H Caldwell, Deborah M Crespo
Mar 3, 2005·European Journal of Radiology·Roger M BourneCynthia L Lean
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jun 9, 2005·Gastroenterology·Vlad RatziuUNKNOWN LIDO Study Group
Aug 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cosimo CollettaMario Pirisi
Jan 27, 2006·World Journal of Gastroenterology : WJG·Monika DezortovaMilan Hajek
Apr 26, 2006·Experimental Biology and Medicine·Vera MichelMarica Bakovic
Jun 3, 2011·Clinics and Research in Hepatology and Gastroenterology·R PaisV Ratziu

❮ Previous
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Citations

Jun 9, 2009·European Radiology·Paul E Sijens
Sep 17, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Xiaozhou MaDushyant V Sahani
Oct 23, 2015·Metabolomics : Official Journal of the Metabolomic Society·Basetti MadhuJohn R Griffiths
Apr 14, 2015·BioMed Research International·Francesco PaparoGian Andrea Rollandi
Apr 19, 2017·Scandinavian Journal of Gastroenterology·Lauri PuustinenPerttu Arkkila
Nov 17, 2009·Journal of Hepatology·Jeremy F L CobboldSimon D Taylor-Robinson
Oct 2, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yunjung LeeHyeonjin Kim
Dec 17, 2009·Topics in Magnetic Resonance Imaging : TMRI·William H PermanIsin Akduman
Jan 27, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qing-Bing WangBei Zhang
May 23, 2014·Transplantation·Yu-Fan ChengChao-Long Chen
Nov 14, 2013·Journal of Magnetic Resonance Imaging : JMRI·Martin GajdošíkMartin Krššák
Jun 27, 2012·AJR. American Journal of Roentgenology·Patrick GeorgoffColleen Hadigan

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