Evaluation of the skin phototoxicity and photosensitivity of honeybee venom

Journal of Cosmetic Dermatology
Sang Mi HanKwanKyu Park

Abstract

Bee (Apis mellifera L.) venom (BV) has been used as a cosmetic ingredient owing to its anti-aging, anti-inflammatory, and antibacterial effects. The aim of this study was to assess the skin safety of BV. For this purpose, skin phototoxicity and sensitization tests were conducted in healthy male Hartley guinea pigs. The animals were divided into three groups (n=5) for the phototoxicity test: G1 (negative control), G2 (BV gel treatment), and G3 (positive control). After specified treatments, the animals were irradiated with ultraviolet A (15 J/cm2 ). The photosensitivity test was also performed in three groups: G4 (negative control, n=5), G5 (BV gel treatment, n=10), and G6 (positive control, n=5). Erythema and edema were observed after 24, 48, and 72 hours in the positive control group, but not in the negative control and BV gel groups. Application of BV to the guinea pig skin had no toxic effects on any clinical signs, body weight, or mortality. In addition, it did not evoke a skin reaction in both either the skin phototoxicity and skin photosensitization tests. Therefore, it can be concluded that BV has the potential to be developed as a drug ingredient for topical uses.

References

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Oct 23, 2015·Clinical Interventions in Aging·Sang Mi HanSok Cheon Pak

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Citations

Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Kurek-GóreckaJerzy Stojko
Feb 27, 2020·Journal of Cosmetic Dermatology·Julie K NguyenJared Jagdeo

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