Evaluation of the Sysmex Xe-2100 hematology analyzer in hospital use

Journal of Clinical Laboratory Analysis
Danièle Nakul-AquaronneJacques Bayle

Abstract

The Sysmex XE-2100 (Sysmex Corp. Kobe, Japan) is a latest-generation hematology analyzer. Its optical and electrical measuring technology is improved by the addition of flux cytometry, fluorescence, and differential lysis. Its analytical performance in terms of precision, reproducibility, linearity, carryover, and time stability was found to be entirely satisfactory. In addition, the results of 500 complete blood counts and differentials correlated perfectly with those obtained by the Coulter STKS (Beckman Coulter, Villapointe, France). The comparison of 500 leukocyte differential count results analyzed in parallel with optical microscopy and the XE-2100 were surprising, and favorable to the XE-2100. This analyzer provides the user with an undeniable feeling of security concerning its reliability in detecting and identifying anomalies in the automated leukocyte differential count. With a sensitivity of 96%, a negative predictive value (NPV) of 98%, and a false-negative (FN) rate of 4%, the XE-2100 has perhaps reached the technological limits for a machine performing morphological recognition of normal and pathological blood cells.

References

Mar 7, 2001·Archives of Pathology & Laboratory Medicine·K RuzickaI Schwarzinger
Apr 25, 2001·Clinical and Laboratory Haematology·C BriggsS J MacHin

❮ Previous
Next ❯

Citations

Feb 28, 2008·Annals of Hematology·Hye Ryoun KimMi Kyung Lee
Aug 21, 2012·PLoS Neglected Tropical Diseases·Bon-A ChoNam-Hyuk Cho
Jul 12, 2008·International Journal of Laboratory Hematology·T GhysJ VAN den Bossche
Aug 30, 2007·Transfusion·Margriet J Dijkstra-TiekstraJanny de Wildt-Eggen
Aug 29, 2012·International Journal of Laboratory Hematology·G ShuG Wu
Jul 31, 2010·International Journal of Laboratory Hematology·G Le RouxFlorence Ajchenbaum-Cymbalista
May 7, 2015·International Journal of Laboratory Hematology·D XiangC Wang
Dec 30, 2015·PloS One·José Gildo de Moura Monteiro JúniorDário Celestino Sobral Filho
Apr 19, 2018·PloS One·José Gildo de Moura Monteiro JúniorDário Celestino Sobral Filho
Jun 26, 2012·The Tohoku Journal of Experimental Medicine·Yong Chul KimHo Jun Chin
Apr 21, 2010·International Journal of Laboratory Hematology·George S CembrowskiD Tung
Apr 7, 2011·Archives of Pathology & Laboratory Medicine·Rafael H JácomoSandra Soares Costa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved