Evaluation of the third trimester amniocentesis for fetal karyotyping in women with fear of pregnancy loss

Journal de gynécologie, obstétrique et biologie de la reproduction
Olivier PiconeR Frydman

Abstract

The aim of this study is to determine the complications of third trimester amniocentesis for fetal karyotyping among women unwilling to accept the fetal loss risks of second trimester amniocentesis. A retrospective study was carried out from January 1998 to December 2006 of 182 singleton pregnancies that underwent a late amniocentesis (after 32 weeks) for fetal karyotyping. The indications were integrated risk (maternal age, first trimester nuchal translucency, second trimester maternal serum markers) over 1/250 (n=68), isolated maternal age over 38 years (n=51), isolated abnormal second trimester biochemical markers (n=34), history of personal or familial a chromosomal abnormality (n=21) or maternal choice (n=8). Presence of fetal abnormalities at ultrasound or context of viral or parasitologic seroconversion as well as multiple pregnancies were considered as non-inclusion criteria. Median maternal age and gestational age at sampling were 39 years (range 23-48) and 32.4 weeks (29.5-37.6). Median interval between amniocentesis and definitive results of amniocentesis on the one hand, and delivery on the on the hand were 15 days (7-42) and 47 days (8-69), respectively. There were no chromosomal abnormality and non-termination of ...Continue Reading

References

May 1, 1996·British Journal of Obstetrics and Gynaecology·N M FiskL Abramsky
Jan 15, 2000·Obstetrics and Gynecology·C M StarkR P Lorenz
Aug 8, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K SchuchterK Philipp
Aug 8, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F AudibertR Frydman
Jan 30, 2002·Obstetrics and Gynecology·Michael C GordonWilliam H Barth
Nov 20, 2002·American Journal of Obstetrics and Gynecology·Anthony M VintzileosRobert A Knuppel
Apr 24, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Babak KhoshnoodFrançois Goffinet
Feb 2, 2006·American Journal of Perinatology·Ercüment MüngenYusuf Ziya Yergök
Apr 6, 2006·American Journal of Perinatology·Jonathan G HodorAlessandro Ghidini
Oct 16, 2007·Fetal Diagnosis and Therapy·Olivier PiconeRene Frydman

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Citations

Aug 13, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rinat Gabbay-BenzivJoseph Pardo

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