Evaluation of the use of low level laser and photosensitizer drugs in healing

Lasers in Surgery and Medicine
Janine Cuzzolin E SilvaAntonio Cláudio Tedesco

Abstract

In the last decade, many different kinds of therapies have emerged as a consequence of advances in the field of applied technology. It is known that low level laser therapy contributes to tissue healing; however, the use of photodynamic therapy (PDT) in healing and the scar formation processes has not been fully explored. The present study analyses the effect of low level laser InGaAIP (685 nm), radiation, either alone or combined with a phthalocyanine-derived photosensitizer (PS) in a gel base delivery (GB) system, on the healing process of cutaneous wounds in rats. The rats were divided into six groups: control (untreated) (CG), gel base (GB), photosensitizer (PS), laser (LG), laser+photosensitizer (LPS), and laser+photosensitizer in a GB (LPSG). Standardized circular wounds were made on the dorsum of each rat with a skin punch biopsy instrument. After wounding, treatment was performed once daily and the animals were killed at day 8. Tissue specimens containing the whole wound area were removed and processed for histological analysis using conventional techniques. Serial cross-sections were analyzed to evaluate the organization of the dermis and epidermis as well as collagen deposition. The animals of groups LG, PS, LPS, and ...Continue Reading

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Citations

Mar 10, 2011·Lasers in Medical Science·Humberto Osvaldo Schwartz-FilhoRosemary Adriana C Marcantonio
Sep 1, 2006·Photomedicine and Laser Surgery·Peter GálJán Sabo
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