Evaluation of the usefulness of protocol-based pharmacist-facilitated laboratory monitoring to ensure the safety of immune checkpoint inhibitors in patients with lung cancer.

Journal of Clinical Pharmacy and Therapeutics
Hiroaki IkesueTohru Hashida

Abstract

Immune checkpoint inhibitors can cause immune-related adverse events (irAEs). Improved monitoring systems for irAEs, which include laboratory tests by a qualified multidisciplinary team, might prevent patients from irAE-associated events. Kobe City Medical Center General Hospital developed protocol-based pharmacist-facilitated laboratory tests named protocol-based pharmacotherapy management (PBPM) to aid the administration of immunotherapy to patients with lung cancer. The protocol defines the laboratory test items and times at which they should be performed. It requires pharmacists to check laboratory orders initiated by physicians and enter additional test items if the orders are incomplete. We evaluated the efficacy of PBPM in irAE monitoring and compared it with those of conventional care systems. From January 2016 to March 2018, 114 patients with lung cancer received immunotherapy, which was managed by conventional care (conventional group). From April to September 2018, 62 patients were managed by PBPM (PBPM group), among those 28 patients were transited from conventional group to PBPM group. Data on whether the laboratory tests were conducted or omitted were collected retrospectively for the conventional group and prospe...Continue Reading

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Citations

Dec 4, 2020·Biological & Pharmaceutical Bulletin·Yoshitaka SaitoMitsuru Sugawara
Aug 3, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshitaka SaitoMitsuru Sugawara

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

JMP

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