Evaluation of the Utility of in utero Treatment of Twin Anemia-Polycythemia Sequence

Fetal Diagnosis and Therapy
Nicolas SananèsR Favre

Abstract

The aim of this study is to evaluate the interest in the in utero treatment of twin anemia-polycythemia sequence (TAPS). The obstetrical and neonatal data on all cases of TAPS followed up in our institution between 2006 and 2013 were reviewed. Statistical analyses were conducted using Bayesian methods. Twenty cases of TAPS were included. Laser therapy or intrauterine transfusion (IUT) was performed on the donor twin in 9 cases. Eleven cases were included in the 'nontreated' group (managed expectantly or diagnosed at birth). The gestational age at diagnosis was lower in the group with treated TAPS [difference (diff) = -22.20 days (-57.13, 14.28), probability (Pr) (diff >0) = 10.6%]. The rate of preterm premature rupture of membranes was higher in the group with treated TAPS [diff = 22.5% (-14, 57), Pr (diff >0) = 89%], but overall mortality was similar. The interval between diagnosis and delivery was longer [diff = 44.37 days (9.41, 77.90), Pr (diff >0) = 99.2%], the TAPS resolution rate was higher [diff = 49.9% (12, 81), Pr (diff >0) = 99.4%], and the neonatal transfusion rate was lower [diff = -30.5% (-60, 0), Pr (diff >0) = 2.6%] in the treated group. In utero treatment for TAPS is associated with a higher resolution rate of ...Continue Reading

Citations

Mar 22, 2016·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Cécile GuenotDavid Baud
Apr 16, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L S A TollenaarUNKNOWN Collaborators

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