Evaluation of therapeutic effect of omega-6 linoleic acid and thymoquinone enriched extracts from Nigella sativa oil in the mitigation of lipidemic oxidative stress in rats

Nutrition
Shafeeque Ahmad, Zafarul H Beg

Abstract

Nigella sativa belongs to the Ranunculaceae family. The therapeutic role of methanolic extract (ME) and volatile oil (VO) fractionated from N. sativa seed oil was investigated for antiperoxidative and antioxidant effects in atherogenic suspension fed rats. We examined the protective effects of ME and VO on the enzymatic and nonenzymatic antioxidants status in erythrocytes and the livers of atherogenic suspension fed rats. As a marker of lipid peroxidation, we estimated the conjugated diene, lipid hydroperoxide, and malondialdehyde concentrations in plasma in the following groups of rats: normolipidemic control, hyperlipidemic control, hyperlipidemic methanolic extract, and hyperlipidemic volatile oil. ME 500 mg or VO 100 mg/kg body weight of male rat was orally administrated for 30 d. Pretreatment of hyperlipidemic rats with these test extracts resulted in a significant decrease (P < 0.001) in the level of lipid peroxidation markers, conjugated diene, lipid hydroperoxide, and malondialdehyde (16-50%) compared to the hyperlipidemic control rats. In addition, ME and VO significantly (P < 0.001) elevated the hepatic and erythrocyte superoxide dismutase, catalase, and glutathione reductase activities (19-58%) compared to the hyperl...Continue Reading

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Citations

Jul 4, 2017·Drug and Chemical Toxicology·Rachid MosbahAlberto Mantovani
Dec 4, 2019·Clinical and Experimental Pharmacology & Physiology·Raushan KumarSyed Ibrahim Rizvi
Dec 4, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Matheus D BaldisseraSilvia G Monteiro
Feb 1, 2017·Critical Reviews in Food Science and Nutrition·Amin F MajdalawiehGheyath K Nasrallah
Jun 20, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Ebrahim M YimerFarooq Anwar
Oct 14, 2020·Phytotherapy Research : PTR·Mohammad Nazrul IslamMd Jamal Uddin

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