PMID: 22466680Oct 1, 2008Paper

Evaluation of therapy with clozapine in outpatient treatment-resistant schizophrenics in Cyprus

Psychiatrikē = Psychiatriki
Y Mikellidis


Clozapine is an atypical antipsychotic formulation indicated for schizophrenic patients who are unresponsive or intolerant to traditional antipsychotic therapy. Treatment with this agent is prevalent among schizophrenic patients under psychiatric hospital care, but not among non-hospitalized patients. The aim of this study was to evaluate the response to clozapine treatment, and specifically the effects on the overall functioning of a group of out-patient treatment-resistant schizophrenics. Data from 66 treatment-resistant schizophrenics in Cyprus, 28 female and 38 male, were retrospectively retrieved. The scales used for assessment were Global Assessment of Functioning Scale (GAF) and the Positive and Negative Syndrome Scale (PANSS). Also, white blood cell (WBC) counts were examined. Based on the GAF scale it was determined that there was a 49.7±23.6 SD point (P < 0.001) significant improvement in the functioning of these patients at the end of the evaluation period with clozapine. Furthermore, utilizing the PANSS, it was concluded that treatment with clozapine significantly improved the positive and negative symptoms as well as the general psychopathology of this patient group. In total, 9 patients were taken off the medicati...Continue Reading

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